Exercise Capacity Before and After AF Ablation in Patients With HFpEF

University of Vermont

Status: Enrolling

Conditions: Atrial Fibrillation; Heart Failure With Preserved Ejection Fraction

Study type: Observational

Funder types: Other

Identifiers

NCT05376748

00001607

Details and patient eligibility

About

In a prospective, observational pilot study of patients scheduled for an atrial fibrillation (AF) ablation at the University of Vermont Medical Center the investigators will compare exercise capacity before and four months after AF ablation.

Full description

Patients ≥ 18 years of age who are scheduled for an AF ablation at the University of Vermont Medical Center will be screened for the following inclusion criteria: H2FpEF score of ≥ 6 (corresponding to ≥90% probability of HFpEF (19)) AND echocardiogram within the past 2 years that reported a LV ejection fraction ≥ 50% AND at least one symptom of HF (dyspnea on exertion, orthopnea or paroxysmal nocturnal dyspnea). Exclusion criteria: (1) Life expectancy <12 months, (2) moderate or more valvular disease, (3) inability to walk on a treadmill. Patients with early recurrent AF (defined as AF after a 12-week post-procedural blanking period accounting for post-ablation inflammation) will be withdrawn from the study and not proceed to the 4 month follow up visit.

Enrollment: 34 estimated patients

Sex: All

Ages: 18 to 110 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• H2FpEF score of ≥ 6 (corresponding to >90% probability of HFpEF (19))
• echocardiogram within the past 2 years that reported a LV ejection fraction ≥ 50%
• at least one symptom of HF (dyspnea on exertion, orthopnea or paroxysmal nocturnal dyspnea).
• AF ablation scheduled at UVMMC

Exclusion criteria

• Life expectancy <12 months
• moderate or more valvular disease
• inability to walk on a treadmill