Exercise Dose-response and Protein Requirements

University of Toronto

Status: Completed

Conditions: Exercise Training

Treatments: Other: Endurance exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT06138951

DRE

Details and patient eligibility

About

Study will investigate the impact of training volume on protein metabolism to estimate the impact on daily protein requirements of endurance athletes.

Enrollment: 7 patients

Sex: Male

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Healthy, male, endurance-trained participants who regularly run more than 40 km/week or perform endurance exercise for more than 4.5 hours/week

• Participants who have a self-reported 5-km run time of ≤23 min
• Participants who are categorized as at least "very good" based on a study by Shvartz & Reibold (Aviat Space Environ Med. 1990 Jan;61(1):3-11), in which VO2peak is used as an index. (i.e. the participants whose VO2peak is ≥57 ml/kg/min (18-24 y), ≥54 ml/kg/min (25-29 y), ≥52 ml/kg/min (30-34 y), ≥49 ml/kg/min (35-39 y)
• Ability to complete the 16-km familiarization run on Session 2
• Aged 18-40 years old

Exclusion criteria

• • Inability to meet health and physical activity guidelines according to the PAR-Q+.
• Female: hormonal fluctuations associated with the menstrual cycle have been reported to alter protein metabolism during exercise and may influence specific amino acid requirements at rest; as such, the present study will test the effect of endurance exercise on protein requirements in males only to ensure a stable hormonal environment and to increase the homogeneity of the physiological response. (NOTE: we plan to test females in a future trial based off of the results obtained herein)
• Inability to adhere to any of the protocol guidelines (i.e. alcohol, caffeine consumption)
• Regular tobacco use
• Illicit drug use (e.g. growth hormone, testosterone, etc.)

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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7 participants in 3 patient groups, including a placebo group

Nonexercised rested day

Placebo Comparator group

Description:

Athlete will not exercise on trial day.

Treatment:

Other: Endurance exercise

Recovery from 10KM run

Experimental group

Description:

Athlete will run 10km on trial day.

Treatment:

Other: Endurance exercise

Recovery from 20KM run

Experimental group

Description:

Athlete will run 20km on trial day.

Treatment:

Other: Endurance exercise