Exercise Dosing for Pain in Healthy Participants

Duquesne University

Status: Completed

Conditions: Pain

Treatments: Behavioral: Control; Behavioral: Walking Exercise

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT03642938

2014-04-22

UL1TR001857 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

In this study investigators will examine the effect of dose related to exercise therapy for pain in healthy adult humans. An acute pain model will be employed to study the effect of exercise dose on pain. Acute pain models are currently used to study pain (both acute and chronic) in human samples as there is currently no chronic pain model.

Full description

This study is designed as a randomized controlled trial with repeated measures. The effect of exercise dose on pain: subjects will be randomly assigned to one of four exercise groups: 1.) no exercise (control); 2.) low dose exercise (3x/week); 3.) moderate dose exercise (5x/week). 4.) high dose exercise (10x/week).

Enrollment: 41 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Between age 18-40
2. Normal BMI (18.5-25.0)
3. Heart Rate (HR) 60-100 bmp
4. BP less than or equal to 140/90

Exclusion criteria

1. Age <18 or >40 years
2. Cardiac, respiratory, neurological or musculoskeletal disease
3. Acute pain
4. Chronic pain condition
5. Diabetes
6. BMI ≥ 25.1 or ≤ 18.4
7. Regular participation in high intensity athletic/sporting activities
8. Sedentary
9. Anxiety or depression disorders
10. Tape allergy
11. Currently pregnant

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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41 participants in 4 patient groups

Low Dose Exercise

Experimental group

Description:

The Low Dose Exercise group will perform treadmill walking exercise, three times per week for one week.

Treatment:

Behavioral: Walking Exercise

Moderate Dose Exercise

Experimental group

Description:

The Moderate Dose Exercise group will perform treadmill walking exercise, five times per week for one week.

Treatment:

Behavioral: Walking Exercise

High Dose Exercise

Experimental group

Description:

The High Dose Exercise group will perform treadmill walking exercise, ten times per week for one week.

Treatment:

Behavioral: Walking Exercise

Control

Sham Comparator group

Description:

The Control group will perform quiet rest, three times per week for one week.

Treatment:

Behavioral: Control