Exercise Echocardiography on LV Mechanics in Patients With CAD: a Speckle-tracking Echocardiography

China Medical University

Status: Unknown

Conditions: NSTEMI; Cardiovascular Diseases; STEMI

Treatments: Other: exercise stress echocardiography

Study type: Observational

Funder types: Other

Identifiers

NCT04824001

CMUH108-REC2-180

Details and patient eligibility

About

Recovering blood flow to a coronary stenosis may improve left ventricular (LV) function in patients with coronary artery disease (CAD). However, the reported data about evaluation of LV function post-percutaneous coronary intervention (PCI) in CAD was limited. The aim of this study was to compare the LV function measured by 3 min low dose exercise stress echocardiography (ESE) combined 2D speckle tracking echocardiography (STE) in patients with CAD underwent PCI, and to identify factors affecting the change of LV function. Patients with CAD who underwent acute PCI were enrolled.

Full description

The assessment of temporal changes in systolic and diastolic regional left ventricle function by 2D-STE after successful reperfusion therapy of acute myocardial infarction (AMI).The estimated total number of participants is 90 patients with AMI and treated with successful percutaneous coronary intervention were included in this study. The echocardiographic measurements were performed in all patients within in-hotpital after PCI procedure, and then followed up at 7, 14, 30, 60 and 180 days after discharge. Recovery of regional systolic and diastolic myocardial function after acute myocardial infarction evaluated by ESE-STE.

Enrollment: 90 estimated patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• acute myocardial infarction diagnosed by a physician
• undergoing percutaneous coronary intervention
• Exercise testing and stress echocardiography are performed with the approval of the physician.

Exclusion criteria

• Severe cardiac valve disease
• Left bundle branch block
• Uncontrolled diabetes or hypertension
• Orthopedics or other conditions that hinder from exercise
• Uncontrolled sinus tachycardia (greater than 120 beats per minute)

Trial design

90 participants in 2 patient groups

STEMI

Description:

ST-segment elevation myocardial infarction (STEMI) is defined by symptoms of myocardial ischemia accompanied by a persistent elevation of the ST segment on the electrocardiogram (ECG) and the subsequent release of biomarkers of myocardial necrosis.

Treatment:

Other: exercise stress echocardiography

NSTEMI

Description:

If there is elevation of the blood markers suggesting heart damage, but no ST elevation seen on the EKG tracing, this is known as a non ST-elevation myocardial infarction (NSTEMI).

Treatment:

Other: exercise stress echocardiography