Exercise Effects on Cardiovascular Risk Factors, Quality of Life, Muscle Function in Type 2 Diabetes and Healthy Persons (SMIDIG)

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Karolinska Institute

Status

Unknown

Conditions

Impaired Glucose Tolerance
Type 2 Diabetes

Treatments

Behavioral: Exercise

Study type

Interventional

Funder types

Other

Identifiers

NCT00852982
ALF 2006 03 25

Details and patient eligibility

About

A sedentary lifestyle is known to be a risk factor to developing type 2 diabetes. The aim of this study was to determine the effects of adding regular Nordic walking to daily physical activity. Effects on quality of life, cardiovascular risk factors and functions in muscle cells will be determined.

Full description

Regular physical activity is known to have a beneficial effect on several factors affecting the risk of developing cardiovascular disease and type 2 diabetes. Implementing and maintaining changes of lifestyle is, however, known to be difficult. In this study we wished to investigate the effects of an exercise intervention that is feasible to most people with type 2 diabetes or at risk of developing that disease. The intervention was Nordic walking (with walking poles) for five hour per week, during four months. We chose to determine effects on health related quality of life, clinical parameters related to body weight/body composition, blood pressure, glucose metabolism, insulin resistance, blood lipids, oxygen uptake and physiological effects in skeletal muscle cells related to glucose metabolism. On inclusion and after four months the participants were therefore subject to clinical measurements, blood samples, maximal oxygen uptake tests on an ergometer cycle and muscle biopsies at inclusion and after four months of participation. They also answered an extensive questionnaire focusing on health related quality of life.

Enrollment

213 estimated patients

Sex

All

Ages

45 to 69 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • BMI>25

Exclusion criteria

  • Physical impairment
  • Symptomatic angina pectoris
  • Insulin treatment

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

213 participants in 2 patient groups

Exercise
Experimental group
Description:
Five hours of Nordic walking per week, during four months
Treatment:
Behavioral: Exercise
Control
No Intervention group
Description:
Control group asked not to alter lifestyle during study
Treatment:
Behavioral: Exercise

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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