Exercise Endothelial Progenitor Cells (EPCs) and Type 2 Diabetes (EPC-DM)

Baltimore VA Medical Center

Status: Active, not recruiting

Conditions: Type 2 Diabetes Mellitus

Treatments: Other: Aerobic Exercise Training

Study type: Interventional

Funder types: Other; Other U.S. Federal agency

Identifiers

NCT01176578

HP-00047188

Details and patient eligibility

About

The discovery of the role of endothelial progenitor cells (EPCs) and their involvement in the cardiovascular complications of type 2 diabetes (T2DM) would quickly have a significant impact on the millions of Americans who have T2DM. This project is designed to 1) determine the mechanisms underlying EPC dysfunction in older, sedentary adults with T2DM compared those with normal glucose metabolism and impaired glucose metabolism, and 2) determine if aerobic exercise training is an efficacious therapy for EPC dysfunction in T2DM, and whether improvement in EPC number and function translates to improved endothelial function, increased capillarization, and improved glucose metabolism in T2DM.

Enrollment: 70 estimated patients

Sex: All

Ages: 50 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 50-80
• Non-smoker
• If woman, postmenopausal >1 year

Exclusion criteria

• History of heart disease or stroke
• Cancer
• Poorly controlled hypertension or dyslipidemia
• Kidney or Liver diseases

Trial design

Primary purpose: Prevention

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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70 participants in 3 patient groups

T2DM

Experimental group

Description:

Type 2 Diabetes Mellitus

Treatment:

Other: Aerobic Exercise Training

IGT

Experimental group

Description:

Impaired Glucose Tolerance

Treatment:

Other: Aerobic Exercise Training

NGT

Active Comparator group

Description:

Normal Glucose Tolerance

Treatment:

Other: Aerobic Exercise Training