Exercise Fatiguability in Older Adults: The Protective Effects of Dietary Nitrate Supplementation

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Marquette University

Status

Enrolling

Conditions

Aging

Treatments

Dietary Supplement: Beetroot Juice
Other: Placebo Beetroot Juice

Study type

Interventional

Funder types

Other

Identifiers

NCT05313490
HR-4040

Details and patient eligibility

About

Vascular and skeletal muscle function decline with age and are associated with decreased nitric oxide (NO) bioavailability. Dietary nitrate supplementation in the form of beet root juice increases NO bioavailability and improves exercise tolerance in younger adults, yet its effects on fatigability in older adults are largely unknown. The proposed research will investigate the impact of increased NO bioavailability on vascular function, skeletal muscle bioenergetics, and fatigability in older (≥65 yrs) men and women.

Enrollment

40 estimated patients

Sex

All

Ages

60 to 90 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Healthy men and women ≥ 60 years old

Exclusion criteria

  1. body mass index ≥40 kg/m2;
  2. type 1 or type 2 diabetes or HbA1c >6.5%
  3. uncontrolled hypertension;
  4. active cancer, cancer in remission, or having received treatment for any form of cancer in the previous five years;
  5. coronary artery disease;
  6. cardiovascular disease (e.g., PAD, PVD);
  7. abnormal and untreated thyroid function;
  8. chronic and/or regular nonsteroidal anti-inflammatory drugs (NSAID) consumption,
  9. tobacco use (includes smoking);
  10. any condition that presents a limitation to exercise (e.g., severe arthritis, COPD, neuromuscular disorder, moderate or severe cognitive impairment, Alzheimer's Disease, severe untreated sleep apnea).

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

Triple Blind

40 participants in 2 patient groups, including a placebo group

Beetroot Juice
Active Comparator group
Description:
The subject will ingest 140mL of a nitrate-rich beetroot juice each day for 7 consecutive days.
Treatment:
Dietary Supplement: Beetroot Juice
Placebo Beetroot Juice
Placebo Comparator group
Description:
The subject will ingest 140mL of a placebo (nitrate-depleted) beetroot juice each day for 7 consecutive days.
Treatment:
Other: Placebo Beetroot Juice

Trial contacts and locations

1

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Central trial contact

Timothy Fulton, PhD

Data sourced from clinicaltrials.gov

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