Exercise Fatiguability in Older Adults: The Protective Effects of Dietary Nitrate Supplementation

Marquette University

Status: Enrolling

Conditions: Aging

Treatments: Dietary Supplement: Beetroot Juice; Other: Placebo Beetroot Juice

Study type: Interventional

Funder types: Other

Identifiers

NCT05313490

HR-4040

Details and patient eligibility

About

Vascular and skeletal muscle function decline with age and are associated with decreased nitric oxide (NO) bioavailability. Dietary nitrate supplementation in the form of beet root juice increases NO bioavailability and improves exercise tolerance in younger adults, yet its effects on fatigability in older adults are largely unknown. The proposed research will investigate the impact of increased NO bioavailability on vascular function, skeletal muscle bioenergetics, and fatigability in older (≥65 yrs) men and women.

Enrollment: 40 estimated patients

Sex: All

Ages: 60 to 90 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy men and women ≥ 60 years old

Exclusion criteria

1. body mass index ≥40 kg/m2;
2. type 1 or type 2 diabetes or HbA1c >6.5%
3. uncontrolled hypertension;
4. active cancer, cancer in remission, or having received treatment for any form of cancer in the previous five years;
5. coronary artery disease;
6. cardiovascular disease (e.g., PAD, PVD);
7. abnormal and untreated thyroid function;
8. chronic and/or regular nonsteroidal anti-inflammatory drugs (NSAID) consumption,
9. tobacco use (includes smoking);
10. any condition that presents a limitation to exercise (e.g., severe arthritis, COPD, neuromuscular disorder, moderate or severe cognitive impairment, Alzheimer's Disease, severe untreated sleep apnea).

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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40 participants in 2 patient groups, including a placebo group

Beetroot Juice

Active Comparator group

Description:

The subject will ingest 140mL of a nitrate-rich beetroot juice each day for 7 consecutive days.

Treatment:

Dietary Supplement: Beetroot Juice

Placebo Beetroot Juice

Placebo Comparator group

Description:

The subject will ingest 140mL of a placebo (nitrate-depleted) beetroot juice each day for 7 consecutive days.

Treatment:

Other: Placebo Beetroot Juice