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This study is designed to find out how engaging in regular exercise (or not) alters the biology of breast tumors as well as the normal tissue (if available) surrounding the tumor. The investigators hope that findings from this initial study will guide the design of future studies to examine how changes in exercise alter breast tumor biology.
Enrollment
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Inclusion criteria
Cohort 1: Breast Cancer Patients
Cohort 2: High-Risk Patients
Women at high-risk of breast cancer, as defined by one of the following:
Aged 21-80 years old
If a female of child-bearing potential, must not be pregnant or planning to become pregnant during the study.
Exclusion criteria
Cohort 1:
Received any form of neoadjuvant treatment
Presence of any other concurrent, actively treated malignancy
Presence of metastatic disease
If performing a CPET, any of the following contraindications:
Mental impairment leading to inability to cooperate
If performing a CPET, room air desaturation at rest ≤ 85%
Any other condition or intercurrent illness that, in the opinion of the investigator, makes the participant a poor candidate for the study.
Cohort 2:
Use of any selective estrogen receptor modulator or aromatase inhibitor within 6 months of consent, including, but not limited to: tamoxifen, raloxifene, arzoxifene, acolbifene, anastrozole, exemestane, and letrozole.
Enrollment on an interventional investigational study
Bilateral breast implants
History of any of the following:
Any current invasive cancer diagnosis
Metastatic malignancy of any kind
If performing a CPET, any of the following contraindications:
Mental impairment leading to inability to cooperate
If performing a CPET, room air desaturation at rest ≤ 85%
Any other condition or intercurrent illness that, in the opinion of the investigator, makes the participant a poor candidate for the core biopsy or the study.
42 participants in 2 patient groups
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Data sourced from clinicaltrials.gov
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