Exercise Genes: Genomic Association With Exercise Reinforcement (ExGenes)

USDA Grand Forks Human Nutrition Research Center

Status: Completed

Conditions: Overweight; Physical Activity; Obesity

Treatments: Other: Resistance Exercise; Other: Sedentary Option; Other: Aerobic Exercise

Study type: Interventional

Funder types: Other U.S. Federal agency

Identifiers

NCT02416882

GFHNRC405

Details and patient eligibility

About

This study tests whether different physical activity patterns are linked an individual's genes.

Full description

The investigators propose that an individual's genetics are one factor that may be associated with the motivating aspect or attractiveness of exercise and therefore the choice to exercise rather than be sedentary. They propose to study the association of the genomic signatures with the reinforcing (motivating) value of different types of exercise. This has never been investigated and may uncover underlying mechanisms that would help to understand individual differences in exercise motivation. The ultimate impact of this work is a greater number of Americans being physically active, meeting the United States Department of Agriculture (USDA) dietary guidelines for physical activity, and maintaining a healthy body weight. This study will be funded and undertaken at the Grand Forks Human Nutrition Research Center (GFHNRC). The purpose will be to assess genetic underpinnings of the motivating value of resistance and aerobic exercise, and to determine whether the motivating value of aerobic and resistance exercise are associated with usual participation in these modes of exercise.

Enrollment: 88 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI within 18.5-35.0 kg/m2
• Healthy enough to exercise
• Active or inactive (not exercising at this time)

Exclusion criteria

• Taking any drugs that affect energy expenditure (e.g., thyroid, glucose-lowering drugs)
• Have gained or lost more than 5% of body weight over the past 6 months
• Use tobacco
• Pregnant or lactating or plan to become pregnant in the next 6 months
• Have any health conditions that prevent the individual from safely exercising (e.g., cardiovascular, liver, endocrine, or pulmonary diseases)

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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88 participants in 2 patient groups

Aerobic Exercise vs Sedentary Option

Other group

Description:

Relative Reinforcing Value of aerobic exercise versus sedentary activity will be determined.

Treatment:

Other: Aerobic Exercise

Other: Sedentary Option

Resistance Exercise vs Sedentary Option

Other group

Description:

Relative Reinforcing Value of resistance exercise versus sedentary activity will be determined.

Treatment:

Other: Sedentary Option

Other: Resistance Exercise