Exercise, Gut Microbiota in Sedentary Adults With Overweight

Universidad Santo Tomas

Status: Withdrawn

Conditions: Metabolic Disturbance

Treatments: Behavioral: HIIT group

Study type: Interventional

Funder types: Other

Identifiers

NCT03515642

DVO005-1-338-CEI882

Details and patient eligibility

About

This project offers the opportunity to obtain detailed measurements on the health of body composition, metabolic health, and intestinal microbial diversity in overweight adults; moreover to provide information about the effects of physical exercise on them. The aim of the research is to advance in the understanding of the mechanisms induced by physical exercise, which includes the measurement of nutritional parameters, clinical and biochemical biomarkers of hepatic/cardiometabolic health, as well as the application of differential proteomics technologies by means of Arrays of cytokines and intestinal microbiome, making this study a novel and pioneer in sensitive areas of primary health care in Latin America.

Sex: Male

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy
• Sedentary males
• BMI>25 kg/m2, on a stable body weight for the last 3 months

Exclusion criteria

• Acute or chronic illness
• Use of antibiotics the past 2 months
• Smoking

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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0 participants in 2 patient groups

HIIT group

Experimental group

Description:

The HIIT modality consisted of 30-40 minutes (min) of steady-state, high-intensity training 3 d/wk on a stationary bicycle at the target heart rate (HR) range equivalent to 85% to 95% of the individual's maximum oxygen consumption rate (VO2max). Exercise will be performed at three sessions per week. All sessions will be supervised by an exercise physiologist during 6-weeks.

Treatment:

Behavioral: HIIT group

SIT group

Active Comparator group

Description:

The SIT modality consisted of 6 to 10 repetitions of a 30 s segment of all-out exercise interspersed with 2 min of recovery, 3 d/wk on a stationary bicycle at the target heart rate (HR) range equivalent to 90% to 95% of the individual's maximum oxygen consumption rate (VO2max).

Treatment:

Behavioral: HIIT group