Exercise in Adolescents With Type 1 Diabetes

Region Örebro County

Status: Active, not recruiting

Conditions: Type 1 Diabetes

Treatments: Other: Exercise bouts

Study type: Interventional

Funder types: Other

Identifiers

NCT04418869

251981

Details and patient eligibility

About

Regular physical activity is an important part of diabetes management in adolescents with type 1 diabetes (T1D). Increased physical activity has several beneficial effects such as improved lipid profile, insulin sensitivity and quality of life. In addition, a reduced HbA1c is often seen in association to increased physical activity. However, the effect on glycemic control and the acute glycemic response seems to differs between different types of exercise. This issue is poorly studied in adolescents with T1D and the mechanism behind this is not fully understood.

The primary aim of this study was to compare the acute effects on glycemia of resistance and two aerobic continuous and intermittent exercise bouts in adolescents with type 1 diabetes. Secondarily, the investigators want to compare the different exercise according to hormonal changes and expression of mRNA in muscle.

At a baseline visit the participants was tested for maximal oxygen consumption (pVO2peak) and maximal strength (1-RM). The study participants then performed three exercise bouts and one control session (resting), each on 45 minutes, in a randomized order. Measurement was performed during and after the exercise.

Enrollment: 8 patients

Sex: Male

Ages: 16 to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Male
• Type 1 diabetes
• HbA1c < 65 mol/mol at inclusion
• Regularly performing physical activity
• Aged 16-18 years old

Exclusion criteria

• Less than 0.5 U/kg in insulin requirements
• Duration of diabetes less than one year.

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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8 participants in 1 patient group

Exercise

Experimental group

Description:

All subject will perform three different exercise bouts and one control session.

Treatment:

Other: Exercise bouts