Exercise in Air Pollution and Lung Health in Asthmatics
Status
Completed
Conditions
Exercise-induced Bronchoconstriction
Air Pollution
Treatments
Drug: Placebo inhalation
Other: Cycling exercise
Other: Filtered air
Other: Diesel Exhaust Exposure
Other: Rest (Sitting on chair)
Drug: Salbutamol inhalation
Details and patient eligibility
About
When exposed to air pollution, the asthma symptoms are aggravated and lung function is impaired. Due to high breathing rates and volumes, physically active individuals are at particular risk of lung health impairment due to the high breathing rates and volumes. Greater doses of air pollutants reach deeper areas in the lungs where they can trigger asthma-symptoms. When treating these symptoms with inhaled beta-2-agonists the airways widen even more, allowing the air pollutants to reach even deeper areas of the lung. With this study the investigators investigate how inhaled beta-2-agonists affect athletic capacity and lung health in physically active asthmatics.
Enrollment
20 estimated patients
Sex
All
Ages
19 to 40 years old
Volunteers
Accepts Healthy Volunteers
Inclusion criteria
- mild-moderate asthmatics with controlled treatment (definition of "mild": percent fall index at eucapnic voluntary hyperpnea (EVH) test on screening day between 10-15%; "moderate": percent fall index at EVH test on screening day between 15 - 20%).
- men and non-pregnant women
Exclusion criteria
- any history of uncontrolled respiratory or cardiac disease
- pregnancy
- allergic reactions to lidocaine and salbutamol
- any recent infections or orthopaedic nasal issues/injuries that may interfere with the insertion of the catheter needed to assess expiratory flow limitation or work of breathing
- claustrophobia in small rooms, comparable to the air pollution chamber used for this study.
- English as a second language (ESL) - participants who are not able to understand the risk that may be associated with the participation in this study due to language difficulties after following the University of British Clinical Research Ethics Board Guidance Notes 13.2.1. (ESL participants will be given a consent form in the most appropriate language or an appropriate translator will be present during the initial consent process).
Trial design
Primary purpose
Basic Science
Allocation
Randomized
Interventional model
Crossover Assignment
Masking
Triple Blind
20 participants in 8 patient groups, including a placebo group
Resting in diesel exhaust following salbutamol inhalation
Active Comparator group
Description:
Participants will be sitting in an air pollution chamber while being exposed to diesel exhaust (PM2.5 of 300 μg/m3) for a total of 1hour following the inhalation of 400ug of salbutamol.
Treatment:
Other: Diesel Exhaust Exposure
Drug: Salbutamol inhalation
Other: Rest (Sitting on chair)
Resting in diesel exhaust following placebo inhalation
Placebo Comparator group
Description:
Participants will be sitting in an air pollution chamber while being exposed to diesel exhaust (PM2.5 of 300 μg/m3) for a total of 1hour following the inhalation of a placebo.
Treatment:
Other: Diesel Exhaust Exposure
Drug: Placebo inhalation
Other: Rest (Sitting on chair)
Cycling in diesel exhaust following salbutamol inhalation
Active Comparator group
Description:
Participants will be cycling while being exposed to diesel exhaust (PM2.5 of 300 μg/m3) for a total of 1 hr following the inhalation of 400ug of salbutamol.
Treatment:
Other: Diesel Exhaust Exposure
Drug: Salbutamol inhalation
Other: Cycling exercise
Cycling in diesel exhaust following placebo inhalation
Placebo Comparator group
Description:
Participants will be cycling while being exposed to diesel exhaust (PM2.5 of 300 μg/m3) for a total of 1 hr following the inhalation of a placebo
Treatment:
Other: Diesel Exhaust Exposure
Drug: Placebo inhalation
Other: Cycling exercise
Resting in filtered air following salbutamol inhalation
Sham Comparator group
Description:
Participants will be sitting while being exposed to filtered air for a total of 1hour following the inhalation of 400ug of salbutamol.
Treatment:
Other: Rest (Sitting on chair)
Other: Filtered air
Resting in filtered air following placebo inhalation
Placebo Comparator group
Description:
Participants will be sitting while being exposed to filtered air for a total of 1hour following the inhalation of a placebo.
Treatment:
Other: Rest (Sitting on chair)
Other: Filtered air
Cycling in filtered air following salbutamol inhalation
Sham Comparator group
Description:
Participants will be cycling while being exposed to filtered air for a total of 1 hr following the inhalation of 400ug of salbutamol.
Treatment:
Drug: Salbutamol inhalation
Other: Cycling exercise
Other: Filtered air
Cycling in filtered air following placebo inhalation
Placebo Comparator group
Description:
Participants will be cycling while being exposed to filtered air for a total of 1 hr following the inhalation of a placebo
Treatment:
Drug: Placebo inhalation
Other: Cycling exercise
Other: Filtered air
Trial contacts and locations
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