Exercise in Breast Cancer Survivors

University of Mississippi

Status: Withdrawn

Conditions: Breast Cancer; Obesity

Treatments: Behavioral: Exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT01582685

2011-0121

Details and patient eligibility

About

The investigators hypothesize that exercise in postmenopausal breast cancer survivors will result in an increase in the plasma concentrations of angiostatic factors and a decrease in the plasma concentrations of angiogenic factors. Exercise is expected to result in a circulating angiostatic phenotype that inhibits adipose tissue mass, growth of breast cancer tumor, growth of microscopic residual disease after breast cancer resection, decreases rates of local-regional recurrence, decreases rates of distant recurrence, and increases survival.

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• > 18 years of age and < 65 years of age
• Female
• BMI > 25
• Weight < 350 pounds
• English as a primary language
• Postmenopausal
• Invasive ER-positive cancer on biopsy and subsequent definitive surgical therapy
• Received and Completed standard of care adjuvant therapy (Concurrent endocrine therapy acceptable)
• 6-12 months after completion of therapy (excluding adjuvant endocrine therapy) at time of randomization

Exclusion criteria

• Recurrent breast cancer
• DCIS only (no invasive component)
• Taking a Beta Blocker or Verapamil
• Pregnant
• Wheelchair bound
• Unable to ambulate independently
• Concurrent uncontrolled medical or psychiatric disorder
• Open wound
• Stage IV breast cancer
• Progression of disease
• Bilateral mastectomies

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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0 participants in 2 patient groups

Exercise Group

Experimental group

Description:

The intervention is a structured walking program which will be performed partly in the Pavilion Physical Therapy clinic and partly at home. The participant will be instructed in how hard to exercise, how long to exercise, and how many times in a week to exercise. You will also be instructed in how to exercise safely.

Treatment:

Behavioral: Exercise

No Exercise

No Intervention group

Description:

These participants will receive standard of care follow up.