Exercise in Health and Chronic Obstructive Pulmonary Disease

Utah System of Higher Education (USHE)

Status: Completed

Conditions: Chronic Obstructive Pulmonary Disease

Treatments: Other: Knee-extensor exercise test; Other: Exercise test with restricting/releasing blood flow; Other: Exercise test with variable oxygen concentration and MRI; Other: Exercise test with oral antioxidant or placebo cocktail

Study type: Interventional

Funder types: Other

Identifiers

NCT02300064

32404

Details and patient eligibility

About

The purpose of this study is to find out more about the effects of chronic obstructive pulmonary disease (COPD) on the function of blood vessels, the heart, and muscle at rest and during exercise.

Full description

Oxidative stress, defined as an imbalance between pro and antioxidant molecular species in favor of the former, has recently been recognized as a potential mechanism in the peripheral muscle dysfunction associated with COPD. a series of studies are proposed to better understand the role and source of oxidative stress in the skeletal muscle of patients with COPD. Specifically, three main aims will address the following questions regarding COPD, skeletal muscle, and oxidative stress: where is oxidative stress most prevalent, why does oxidative stress occur, and what are the consequences of oxidative stress in COPD? the overall hypothesis to be tested is that COPD results in a shift toward greater intramuscular oxidative stress and this is, at least in part, responsible for the diminished mechanical efficiency and greater peripheral muscle fatiguability during muscular work often associated with this disease. The vascular consequence of this augmented free radical load is altered vascular function and a disruption of the local matching of perfusion and metabolism in skeletal muscle during exercise. These crucial changes result in a cascade of factors such as local hypoxia and elevated vascular shear stress, entering a vicious cycle that leads to the generation of more free radicals, especially during physical work. It is proposed that this imbalance between pro and antioxidant potential, toward oxidative stress, plays a significant role in the attenuated exercise capacity and reduced muscle fatigue resistance associated with COPD.

Enrollment: 185 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Chronic Obstructive Pulmonary Disease (COPD) patients (over 18 years old) and
• age-matched healthy controls (over 18 years old)

Exclusion criteria

• Severe Chronic Obstructive Pulmonary Disease (volume exhaled at the end of the first section of forced expiration is predicted to be under 30 percent),
• Severe Heart Failure

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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185 participants in 2 patient groups

Healthy volunteers

Experimental group

Description:

Healthy volunteers will undergo one or more exercise interventions: knee-extensor exercise test; exercise test with restricting/releasing blood flow; exercise test with variable oxygen concentration and MRI; or exercise test with oral antioxidant or placebo cocktail.

Treatment:

Other: Exercise test with restricting/releasing blood flow

Other: Exercise test with oral antioxidant or placebo cocktail

Other: Exercise test with variable oxygen concentration and MRI

Other: Knee-extensor exercise test

COPD patients

Experimental group

Description:

Patients with Chronic Obstructive Pulmonary Disease (COPD) will undergo one or more exercise interventions: knee-extensor exercise test; exercise test with restricting/releasing blood flow; exercise test with variable oxygen concentration and MRI; or exercise test with oral antioxidant or placebo cocktail.

Treatment:

Other: Exercise test with restricting/releasing blood flow

Other: Exercise test with oral antioxidant or placebo cocktail

Other: Exercise test with variable oxygen concentration and MRI

Other: Knee-extensor exercise test