Exercise in Hypoxia and Nitrate Supplementation in Athletes: is the Whole Greater Than the Sum of Its Parts?

University of Trás-os-Montes and Alto Douro

Status: Completed

Conditions: Hypoxia

Treatments: Other: Control; Dietary Supplement: Placebo + Hypoxia; Combination Product: Nitrate + Hypoxia

Study type: Interventional

Funder types: Other

Identifiers

NCT06727656

Hypoxia

Details and patient eligibility

About

Determine the combined effect of training in hypoxia and nitrate supplementation on the performance and health of athletes at sea-level and altitude conditions.

Full description

Determine the combined effect of training in hypoxia and nitrate supplementation on the performance and health of athletes at sea-level and altitude conditions. It is hypothesized that the combined effect of these interventions will promote an additional performance and health improvement in this population at sea-level and altitude conditions, compared with the single effect.

Enrollment: 30 patients

Sex: Male

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• trained male subjects, regularly involved in competitive running, cycling and/ or triathlon events (4-5 times per week) in the past five years

Exclusion criteria

• smoking or other chronic issues
• using medication or dietary supplements in the last 3 months, or during the duration of the study
• being exposed to altitude (≥2000 m) in the last 3 months

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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30 participants in 3 patient groups, including a placebo group

HNO: High intensity interval training (HIIT) + nitrate supllementation (NO3-).

Experimental group

Description:

Performed 12 high-intensity interval-training (HIIT) sessions during a 4-week period (3 sessions/ week) under normobaric hypoxia conditions (FiO2=\~13%, \~3000 m) with NO3- supplement.

Treatment:

Combination Product: Nitrate + Hypoxia

HPL: High intensity interval training (HIIT) + placebo supllementation.

Active Comparator group

Description:

Performed 12 high-intensity interval-training (HIIT) sessions during a 4-week period (3 sessions/ week) under normobaric hypoxia conditions (FiO2=\~13%, \~3000 m) with placebo supplement.

Treatment:

Dietary Supplement: Placebo + Hypoxia

CON: High intensity interval training (HIIT) + placebo supllementation.

Placebo Comparator group

Description:

Performed 12 high-intensity interval-training (HIIT) sessions during a 4-week period (3 sessions/ week) under normoxic conditions (FiO2=\~20.9%) with placebo supplement.

Treatment:

Other: Control