Exercise-induced High-sensitivity Troponin Levels as a Predictor for Obstructive Coronary Artery Disease (EUROCAD)

Universitaire Ziekenhuizen KU Leuven

Status: Unknown

Conditions: Coronary Artery Disease

Study type: Observational

Funder types: Other

Identifiers

NCT02626806

UZL9281

Details and patient eligibility

About

1. To compare hs-TnT levels after a cardiac stress test in patients with vs. patients without CAD
2. To assess the level of post-exercise hs-TnT predicting CAD (using ROC-analysis)
3. To determine the sensitivity, specificity and accuracy of this exercise-induced hsTopT level in predicting CAD, either alone or in relation to traditional patient-related and exercise test-related metrics

Enrollment: 150 estimated patients

Sex: All

Ages: 18 to 99 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Patients with suspected CAD, planned for diagnostic coronary angiogram
2. Patients with previous revascularization, suspected of recurrent ischemia

Exclusion criteria

1. Congestive cardiomyopathy with LV EF < 35%
2. Renal failure with eGFR < 30 ml/min
3. Known structural or severe valvular heart disease
4. Prior CABG
5. Previous ACS < 6 weeks
6. Known incomplete revascularization after previous PCI
7. Unstable angina or ACS (defined as unstable anginal symptoms + ECG changes or hs-TnT > 0.053 ng/L)

Trial design

150 participants in 2 patient groups

patients with hemodynamic significant CAD;

patients without hemodynamic significant CAD