Exercise-Induced Metabolic Compensation; a Physiological Adaptive Response to Exercise Training

Tel Aviv University

Status: Active, not recruiting

Conditions: Exercise Training

Treatments: Behavioral: Exercise training

Study type: Interventional

Funder types: Other

Identifiers

NCT04460040

Metabolism

Details and patient eligibility

About

The primary aim of this proposal is to identify changes in the volume of highly metabolic organs (liver, kidneys, and brain) that occur as a physiological adaptation to exercise training and lower the resting energy expenditure. Secondary aims are to identify changes in the metabolic efficiency of muscle in low levels of physical activity and evaluate the effects on components of total daily energy expenditure including the sleeping metabolic rate (SMR) and diet induced thermogenesis (DIT).

Full description

Using a clinical trial type protocol, 16 overweight (body mass index: 25-30 kg/m2) men (n=8) and women (n=8) aged 21 to 45 years will exercise for 3 months in a moderate intensity regimen of 20 kcal/week/kg body weight that reflects current recommendations for weight management. The volume of various organs will be measured pre- and post-exercise intervention using magnetic resonance imaging (MRI). A cycling ergometer with a varied workload will be used to assess muscle metabolic efficiency. Changes in overnight SMR and 4 hours post breakfast DIT will be evaluated by whole human room indirect calorimetry ("metabolic chamber"). In addition, free-living Total Energy Expenditure (TEE) will be measured for ten days pre- and post-intervention by doubly labeled water.

Enrollment: 16 estimated patients

Sex: All

Ages: 21 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Overweight [body mass index (BMI) 25-30

Exclusion criteria

• Participation in another exercise or weight loss program in the last 6 months
• Non-stable weight (>±5%) over the past 6 months
• Current regular exercise > 1 hour per week
• Smoking within the past 6 months
• Being post-menopausal, breastfeeding, pregnancy, or having been pregnant within the past 6 months
• Previous bariatric surgery
• Cardiopulmonary disease (e.g., recent myocardial infarction or unstable angina)
• Musculoskeletal or neuromuscular impairments that preclude exercise training
• Having other health issues include cancer, diabetes, thyroid disease, hypertension, chronic renal failure, cognitive impairments
• Use of drugs that potentially impact body metabolism.

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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16 participants in 1 patient group

Intervention

Experimental group

Description:

Exercise in moderate intensity tailored individually to 20 kcal/kg/week (range 1500-2000 kcal/week) with a free choice to exercise at home/gym on a treadmill or outdoors.

Treatment:

Behavioral: Exercise training