Exercise Intensity and Appetite in Adolescents

Université Blaise Pascal, Clermont-Ferrand

Status: Unknown

Conditions: Pediatric Obesity

Treatments: Behavioral: acute exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT02484612

AME2P Laboratory

Details and patient eligibility

About

Acute exercise has been shown to affect subsequent energy intake in obese adolescents. Indeed, it has been shown several times that an intensive bout of exercise (above 70% of the individual maximal capacities) can reduce energy intake at the following meal in obese adolescents, with no modification of his appetite feelings.

Although this results has been replicated several times, it remains unknown if those nutritional adaptations are due to post-exercise modifications of some gastro-peptides implicated in appetite control, as detailed in adults.

The aim of this work is to question whether or not post-exercise energy intake is explained by appetite-regulating hormones that are affected by the exercise bout in both lean and obese youth.

Full description

After an first medical visit to ensure that the adolescents have the ability to complete the whole study, the participants will have to complete several clinical examinations:

• anthropometric measurements
• Body composition assessed by dual energy x-ray absorptiometry
• Maximal aerobic test

They will then randomly complete the following conditions:

• CON: a control day without exercise;
• HIE: an exercise day with an exercise set at 75% of the capacities
• LIE: an exercise day with an exercise set at 40% of the capacities

The exercises or the rest condition will be done by the end of the morning and a buffet meal will be proposed during which the participants will be asked to eat as much as wanted.

Blood samples will be drawn before, after, 15 after and 30 minutes after the exercise to assess the main appetite regulating hormones involved in appetite regulation (PYY, Cholecystokinin ...) appetite feelings will be assessed throughout the day at regular interval using visual analogue scales.

Enrollment: 30 estimated patients

Sex: Male

Ages: 12 to 15 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 12 to 15 years old adolescents
• Obese according to international values for BMI
• Being registered to the national social security insurance
• no eating disorders
• no medications
• metabolic disorders

Exclusion criteria

• metabolic disorders
• food disorders
• physical disability

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: None (Open label)

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30 participants in 2 patient groups

Lean adolescents

Experimental group

Description:

15 lean adolescents (BMI Under the national cut-offs for obesity), 12-15 years old, males, will be recruited

Treatment:

Behavioral: acute exercise

Obese adolescents

Experimental group

Description:

15 obese adolescents (BMI above the national cut-offs for obesity), 12-15 years old, males, will be recruited

Treatment:

Behavioral: acute exercise