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Exercise Intervention in Adolescent and Young Adult Cancer Survivors

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Indiana University

Status

Enrolling

Conditions

Long-term Effects Secondary to Cancer Therapy in Adults
Pediatric Cancer

Treatments

Behavioral: Exercise

Study type

Interventional

Funder types

Other

Identifiers

NCT04265638
IUSCC-0696

Details and patient eligibility

About

Adolescent and young adult (AYA) survivors of cancer face a future of persistent medical issues across a wide spectrum of diseases One study examining health data from this cohort (ages 15-29) reported significantly higher rates of smoking, obesity, cardiovascular disease, hypertension, asthma, and poorer mental health among the cancer survivors when compared to healthy controls. Prescribed exercise has broad and far-reaching beneficial physiological effects that cut across multiple body systems and consistently improves emotional well-being, decreases fatigue and depression, and enhances quality of life. Although a growing body of evidence consistently demonstrates the physiological and psychological benefits of exercise interventions in adults with cancer, there are no studies examining the effects of individualized, prescribed, supervised exercise in pediatric, adolescent and young adult cancer survivors.

Enrollment

66 estimated patients

Sex

All

Ages

15 to 39 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  1. Age ≥ 15 and ≤ 39 years,
  2. History of cancer
  3. At least three months off of cytotoxic chemotherapy (note: hormone therapy is permitted)

Exclusion criteria

  1. Evidence of significant liver dysfunction, congestive heart failure, cardiovascular disease
  2. History of CNS tumor
  3. Down's Syndrome
  4. Unable to perform aerobic and/or strength exercises with full range of motion (limb immobilization, limb amputation, or surgical complications.
  5. Neurological disorder
  6. Baseline exercise of 30 minutes per day three times a week already being performed.

Trial design

Primary purpose

Supportive Care

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

66 participants in 2 patient groups

Exercise
Experimental group
Treatment:
Behavioral: Exercise
Usual Care
No Intervention group

Trial contacts and locations

3

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Central trial contact

NiCole Keith, PhD

Data sourced from clinicaltrials.gov

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