Exercise Intervention in Patients With Metabolic Syndrome and Renal Disease: a Prospective Study (EXRED)

University of La Laguna

Status

Completed

Conditions

CKD

Metabolic Syndrome

Treatments

Other: Therapeutic exercise

Study type

Interventional

Funder types

Other

Identifiers

NCT06576518

CHUC_2021_32

Details and patient eligibility

About

INTRODUCTION: Obesity (OB) and metabolic syndrome (MetS) are risk and progression factors for chronic kidney disease (CKD). However, the effect of OB/MetS intervention with exercise on renal function progression and proteinuria is unknown.

OBJECTIVE: To analyse the effect of therapeutic exercise on MetS and main renal outcomes in patients with CKD.

METHODOLOGY: This is a 6-month prospective exploratory study. Patients with stablished CKD (1-4) and MetS were treated with individualised incremental exercise (aerobic and resistance). Simultaneously, a plan of adherence was set up to promote compliance. Renal and metabolic outcomes were collected. The main renal parameters were: proteinuria, in isolated urine samples, and glomerular filtration rate (GFR), measured by iohexol DBS, at 0, 3 and 6 months. At the same time points, metabolic outcomes were measured: weight, dyslipidemia, insulin resistance and hypertension.

Enrollment

50 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

age >18 years
CKD of diverse aetiologies
estimated GFR ≥ 30 ml/min
BMI ≥ 27 kg/m2 associated to MetS or diabetes mellitus (DM)
stable renal function for at least 6 months before screening
ability to perform exercise

Exclusion criteria

clinical conditions that exclude exercise therapy such as clinical instability, active infection, cancer, acute cardiovascular disease, advanced CKD, pulmonary hypertension, or limb amputations
inability to understand the protocol
severe psychiatric illness
allergy to iodine