Exercise or Relaxation for Smoking Cessation

UConn Health

Status

Completed

Conditions

Nicotine Dependence

Smoking Cessation

Treatments

Behavioral: Exercise or relaxation treatment

Other: Varenicline and smoking cessation counseling

Study type

Interventional

Funder types

Other

NIH

Identifiers

NCT00921388

1R01DA024872-01A1 (U.S. NIH Grant/Contract)

09-097-2

Details and patient eligibility

About

This research study is being done to find out if adding a moderate exercise program or a relaxation program to a smoking cessation treatment program will improve smoking cessation and health in postmenopausal women. We hope to learn which group is more successful at quitting, has less symptoms of withdrawal from smoking and has improved health.

Full description

Prevalence of smoking among women has declined more slowly in women than among men. Women who quit smoking substantially reduce the risk of premature death. A multi-modal approach to smoking cessation with combined behavioral and pharmacological interventions generally yields the highest success rates. The majority of subjects who are able to achieve abstinence return to smoking. Smoking relapse rates are 50-80% within one year with the majority of smokers relapsing within the first 3 months. Interventions are needed to both enhance smoking cessation rates and prevent relapse rates in order to substantially impact long-term quit rates.We intend to compare the effectiveness of a smoking cessation program combined with a moderate exercise program to an identical smoking cessation program combined with a relaxation-meditation control condition.

In a substudy, we will also evaluate the effectiveness of the intervention in premenopausal women (N=40)

Enrollment

301 patients

Sex

Female

Ages

45+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Postmenopausal women at least 45 years of age
Smoking at least 10 cigarettes per day
Motivated to quit smoking
Ambulatory
Currently exercising for 90 minutes of moderate exercise or less per week
Motivated to exercise
Permission from Primary Care Provider
Good general health

Exclusion criteria

Denied medical clearance from primary care provider
Unstable angina or uncompensated heart failure
Systolic blood pressure greater than 165 or diastolic blood pressure greater than 100
Heart attack or stroke within the preceding 6 months
Hip fracture within the preceding 6 months
Unstable medical or psychiatric disorder (e.g., current major depressive disorder or substance abuse or dependence)
Exercise-exacerbated neuromuscular disorder
Treatment for depression within the last year
Estimated creatinine clearance of less than 30cc/minute
Current use of a smoking cessation aid (i.e., bupropion, NRT, clonidine)
Current use of psychotropic medication for a psychiatric problem
Prescription narcotic abuse or dependence with the exception of people that have been stabilized on Methadone Maintenance or Suboxone
Previous serious adverse event with Chantix use