ClinicalTrials.Veeva

Menu

Exercise Prehab in Older Adults With Hematologic Malignancies

The Ohio State University logo

The Ohio State University

Status

Unknown

Conditions

Hematopoietic and Lymphoid Cell Neoplasm

Treatments

Other: Quality-of-Life Assessment
Procedure: Physical Therapy
Other: Laboratory Biomarker Analysis
Behavioral: Exercise Intervention
Other: Questionnaire Administration

Study type

Interventional

Funder types

Other
NIH

Identifiers

NCT02791737
NCI-2016-00446 (Registry Identifier)
OSU-16016 (Other Identifier)
P30CA016058 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

This pilot trial studies a structured exercise program intervention in improving physical activity in older patients with hematologic malignancies undergoing cancer therapy. Patients with hematologic malignancies are at an increased risk of functional dependence and injury. Structured exercise programs, such as the Otago exercise programme (OEP), may improve balance, strength, and prevent fall-related injury in older patients with hematologic malignancies undergoing cancer therapy.

Full description

PRIMARY OBJECTIVES:

I. To assess the feasibility of implementing a structured exercise program by evaluating recruitment and retention, exercise program adherence, sustainability, adverse events, and implementation challenge.

SECONDARY OBJECTIVES:

I. To calculate preliminary effect sizes of the impact of an exercise program in patients with hematologic malignancy undergoing therapy, as measured by:

  • Cancer and Aging Research Group (CARG) Geriatric Assessment Tool parameters.
  • Change in Short Physical Performance Battery (SPPB).
  • Number and severity of falls.
  • Impact of motivation and self-efficacy on adherence.
  • Hospital readmission rates (if applicable).
  • Length of inpatient stays (if applicable).
  • Patient Reported Outcome Measurement Information System (PROMIS) for Health related quality of life (HRQL).
  • Correlative analysis of peripheral blood biomarkers of aging and inflammation (cyclin-dependent kinase inhibitor 2A [p16], inflammatory biomarkers, immunosenescence, micro [mi] ribonucleic acid [RNA]).

OUTLINE:

Patients attend 8 physical therapy visits twice monthly for 4 months or until transplant. Patients also undergo an individualized exercise program at home for 6 months. The program comprises 3 main components: walking over 30 minutes twice a week, strengthening and balance retraining exercise over 30 minutes three times a week.

After completion of study, patients are followed up at 6 months.

Enrollment

30 estimated patients

Sex

All

Ages

60+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Patients with hematologic malignancy receiving care (chemotherapy, immunotherapy, targeted agents, bone marrow transplant, or other) for their hematologic malignancy at the Ohio State University
  • Impairments in physical function, as defined by a score < 9 on the SPPB pre-screen
  • Medical clearance from an oncologist or primary care physician stating the participant is able to participate in an unsupervised, moderate-intensity physical activity program
  • Ability to understand and the willingness to sign a written informed consent document

Exclusion criteria

  • Prisoners
  • Any medical condition including, but not limited to, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness that would limit compliance with study procedures

Trial design

Primary purpose

Supportive Care

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

30 participants in 1 patient group

Supportive care (otago exercise programme)
Experimental group
Description:
Patients attend 8 physical therapy visits twice monthly for 4 months or until transplant. Patients also undergo an individualized exercise program at home for 6 months. The program comprises 3 main components: walking over 30 minutes twice a week, strengthening and balance retraining exercise over 30 minutes three times a week.
Treatment:
Other: Questionnaire Administration
Behavioral: Exercise Intervention
Other: Laboratory Biomarker Analysis
Other: Quality-of-Life Assessment
Procedure: Physical Therapy

Trial contacts and locations

1

Loading...

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2025 Veeva Systems