Exercise Prehabilitation for Locoregional Esophageal Cancer

H. Lee Moffitt Cancer Center and Research Institute

Status: Enrolling

Conditions: Esophageal Cancer

Treatments: Behavioral: Exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT06430346

MCC-23121

Details and patient eligibility

About

The purpose of the study is to examine the feasibility and acceptability of exercise "prehabilitation" for patients preparing for esophageal cancer resection (removal).

Enrollment: 20 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Biopsy-proven locoregional esophageal cancer (LEC)
• Eastern Cooperative Oncology Group (ECOG) performance status 0-2
• Treatment plan including neoadjuvant chemoradiation therapy and surgical resection
• Ability to read and speak English

Exclusion criteria

• Regular engagement in resistance training (2x/week targeting all major muscle groups)
• Screen failure for exercise safety based on PAR-Q
• Underlying unstable cardiac or pulmonary disease or symptomatic cardiac disease
• Recent fracture or acute musculoskeletal injury that precludes ability to participate in resistance training safely
• Numeric pain rating scale of 7 or more out of 10
• Myopathic or rheumatologic disease that impacts physical function

Trial design

Primary purpose: Supportive Care

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 1 patient group

Exercise prehabilitation

Experimental group

Description:

In this trial participants will participate in an exercise program for 5 to 17 weeks, varying with treatment plans. Participants will receive resistance training equipment and participate in resistance training sessions twice per week (approximately 30-45 minutes per session). A Fitbit device will be provided to monitor step counts.

Treatment:

Behavioral: Exercise