Exercise Pulmonary Transit Time

Vanderbilt University Medical Center

Status and phase: Completed; Phase 4

Conditions: Heart Failure, Diastolic

Treatments: Diagnostic Test: contrast echocardiography

Study type: Interventional

Funder types: Other

Identifiers

NCT04336995

IRB200429

Details and patient eligibility

About

The study seeks to measure pulmonary transit time via contrast-echocardiography before and after exercise.

Full description

The ability to measure the amount of blood in the lungs using heart-ultrasound (echocardiography) can be useful to estimate how much fluid is in a patient's circulation, which can influence diagnosis and treatment of certain types of heart failure. In some patients, the amount of fluid is normal at rest, but can increase with activity and thus a diagnosis of heart failure can only be made after exercising. Currently, the amount of fluid is measured invasively. We have shown that echocardiography can measure the amount of fluid in the lung circulation at rest without the need for an invasive procedure. We now seek to find out if we can make a similar measurement after exercise. If successful, the need for catheter procedures may be reduced in certain types of heart failure.

Enrollment: 14 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Age ≥ 18 years old
2. Able to give informed consent

Exclusion criteria

1. Known allergic reaction to Definity or Optison ultrasound contrast
2. Pregnancy/Nursing - as assessed/disclosed by the participant

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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14 participants in 1 patient group

Exercise

Other group

Description:

Everyone is in this arm

Treatment:

Diagnostic Test: contrast echocardiography