Exercise Response After Revalidation in Cancer Patients

Universitair Ziekenhuis Brussel

Status: Unknown

Conditions: Cardiac Toxicity; Oncology

Treatments: Diagnostic Test: Cardiorespiratory exercise test

Study type: Interventional

Funder types: Other

Identifiers

NCT04461392

BC032020_1

Details and patient eligibility

About

This study regarding oncological patients for rehabilitation after specific cancer therapy involves three aims: (1) to evaluate the predictive value of myocardial work parameters on the improvement of exercise performance after rehabilitation, (2) to determine which echocardiographic parameters are more suitable in predicting cardiac dysfunction, and (3) to evaluate the correlation between echocardiographic parameters and fibrosis detected by cardiac magnetic resonance imaging (CMR).

Full description

Myocardial work (MW) provides an estimation of cardiac function by combining global longitudinal strain (GLS) with blood pressure values obtained non-invasively, being less load dependent than standard GLS. The investigator hypothesize that myocardial work could be a useful marker for predicting the exercise performance after chemotherapy and/or radiotherapy in oncological patients undergoing rehabilitation. Moreover, this study may provide additional information in optimal selection for rehabilitation programs.

Enrollment: 191 estimated patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Patients diagnosed with cancer
2. Undergoing chemotherapy and/or radiotherapy/hormone therapy
3. Age older than 18 years old - maximum age of 90 years old
4. Willing to enter revalidation in Universitair Ziekenhuis Brussel
5. Signed consent form

Exclusion criteria

1. Severe aortic stenosis defined as aortic valve aria under 0.6 cm2/m2
2. Supraventricular arrhythmias
3. Poor image quality for 2D and 3D echocardiography defined as the impossibility to examine of more than 2 adjacent segments
4. Resistant hypertension defined as uncontrolled blood pressure values under current European guidelines, Systolic Blood Pressure more than 140 mmHg and/or Diastolic Blood Pressure more than 80 mmHg
5. Lung cancer

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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191 participants in 1 patient group

Oncology patients

Experimental group

Description:

Patients diagnosed with cancer and treated with chemotherapy and/or radiotherapy

Treatment:

Diagnostic Test: Cardiorespiratory exercise test