Exercise-stimulated Muscle Glucose Uptake in Upper Body Obesity

Mayo Clinic

Status

Active, not recruiting

Conditions

Upper Body Obesity

Treatments

Other: Exercise

Study type

Interventional

Funder types

Other

NIH

Identifiers

NCT04532814

R01DK045343 (U.S. NIH Grant/Contract)

20-002949

Details and patient eligibility

About

The purpose of this study is to provide the first integrated examination of the interaction between muscle insulin action and exercise-stimulated muscle glucose uptake in obesity from the whole body to the cellular/molecular level.

Enrollment

48 estimated patients

Sex

All

Ages

18 to 55 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

For the exercise studies of leg glucose uptake - "insulin sensitive" group:

Sedentary, normal weight, premenopausal women.
Sedentary, age-matched normal weight men.
Weight stable for two (2) months prior to study.
Willing to provide written, informed consent.
For the exercise studies of leg glucose uptake - "insulin resistant" group:

For the exercise studies of leg glucose uptake - "insulin resistant" group:

Upper body obese (UBO) premenopausal women.
Age-matched upper body obese (UBO) men.
Weight stable for two (2) months prior to study.
Willing to provide written, informed consent.

Exclusion criteria

Age < 18 or > 55 years (premenopausal women and age-matched men).
Use of glucose-lowering agents.
For female subjects: positive pregnancy test at the time of enrollment or study
History of prior upper abdominal surgery such as adjustable gastric banding, pyloroplasty and vagotomy.
Active systemic illness or malignancy.
Symptomatic macrovascular or microvascular disease.