Exercise Study in Patients With Lung Cancer (POSITIVE)

German Cancer Research Center

Status and phase: Completed; Phase 2

Conditions: Non Small Cell Lung Cancer

Treatments: Other: Exercise intervention

Study type: Interventional

Funder types: Other

Identifiers

NCT01581346

POSITIVE_II

Details and patient eligibility

About

In the course of their disease patients with Non small cell lung cancer (NSCLC) often experience impaired psychological and physical functioning resulting in a reduced quality of life (QoL). The aim of the study is to explore the feasibility and the effects of an eight weeks combined muscle strength and endurance training on physical capacity and QoL.

Full description

In this open, prospective, single center study 40 patients (pts) with NSCLC undergoing adjuvant or palliative chemo-/ or radiotherapy are enrolled. Physical status is assessed by using the 6 Minute Walk Test (6MWT) for endurance and by using the Handheld Dynamometer (HHDM) for strength (flexion and extension of elbow, hip and knee). Psychological performance is measured by standardized questionnaires (MFI, FACT-L, PHQ - 9). Data are collected at baseline (T0) and after the 8 weeks sports intervention (T1). Pts are instructed to train at least 5 times/ week in the inpatient setting. After discharge pts are instructed to train in a home-based setting at least 3 times/week for a period of 8 weeks. Feasibility is defined as an adherence of two trainings per week during at least 6 weeks (out of 8 weeks of the intervention).

Enrollment: 40 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Male and female patients
• histological confirmed diagnosis of Non small cell lung cancer (NSCLC)
• current treatment: chemo-and/or radiotherapy
• age > 18y
• Body Mass Index (BMI) > 18
• written informed consent

Exclusion criteria

• acute infection
• immobility > 2 days
• severe neurological impairment
• severe cardiac impairment
• severe pulmonal impairment
• severe renal impairment
• acute bleedings
• alcohol-/drug-abuse

Trial design

40 participants in 1 patient group

exercise intervention

Experimental group

Description:

Pts were instructed to train at least 5 times/ week in the inpatient setting. After discharge pts were instructed to train in a home-based setting at least 3 times/week for a period of 8 weeks.

Treatment:

Other: Exercise intervention