Exercise Target Brain Oscillations in Psychosis

University of Minnesota (UMN)

Status: Withdrawn

Conditions: Schizophrenia; Psychosis; Schizoaffective Disorder

Treatments: Other: Sprint Interval Training (SIT)

Study type: Observational

Funder types: Other

Identifiers

NCT05338424

PSYCH-2022-30666

Details and patient eligibility

About

Previous studies have shown that cardiorespiratory fitness (how well the heart and lungs are able to function during physical activity) is often reduced in people with psychosis. The goal of this research study is to test the hypothesis that aerobic exercise can lead to small changes in brain functioning that can influence visual perception and attention in psychosis. The type of aerobic exercise used in this study is called Sprint Interval Training, or "SIT". Information from this study will help to develop interventions that enhance cognition and maximize the quality of life for persons living with psychosis.

The exercise procedure used is called SIT, which involves training rigorously on a stationary bike for a short period of time followed by a resting period.

Sex: All

Ages: 18 to 64 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Meet diagnostic criteria for schizophrenia or schizoaffective disorder
• Are age 18-64
• Fluent in written and spoken English
• Have an outpatient status of at least 1 month prior to participation
• Has been on a stable dose of psychiatric medication for at least one month prior to participation (titration to a lower dose of psychotropic medications under supervision of a psychiatrist can be allowed at the discretion of the investigators)

Exclusion criteria

• Current or possibility of current pregnancy (self-reported)
• Active suicidal ideation at screening or baseline assessments, or previous intent to act on suicidal ideation with a specific plan, preparatory acts, or an actual suicide attempt within the last 3 months, as indicated by the C-SSRS
• WTAR standardized score below 70
• American College of Sports Medicine contraindication to exercise

Trial design

0 participants in 2 patient groups

Sprint Interval Training (SIT)

Description:

The 1-session SIT protocol will include "Work" bouts performed at maximal intensity targets. Three "Work" bouts will be performed at 20-second intervals separated by 2 recovery bouts consisting of 2 minutes of low-intensity cycling. The SIT session will employ a standardized warm up and cool down of 3 minutes at a self-selected light intensity, per current guidelines. SIT sessions will take 15 minutes to complete.

Treatment:

Other: Sprint Interval Training (SIT)

Stretching

Description:

Stretching will include a low-intensity range of motion and stretching exercises with session duration (15 minutes) being matched to SIT.