Exercise Test and Cardiac Injury

Radboud University Medical Center

Status

Completed

Conditions

Cardiovascular Disease

Treatments

Other: remote ischemic preconditioning (RIPC)

Study type

Interventional

Funder types

Other

Identifiers

NCT01660828

EXTROP2

Details and patient eligibility

About

Strenuous exercise in apparent healthy individuals increases plasma (high sensitive) troponin levels. The underlying mechanism is not yet elucidated, but could be explained by changes due to a mismatch in oxygen demand and supply that mimic those of ischemia and reperfusion injury. If the mechanism underlying the troponin release during exercise is similar to that of ischemia reperfusion injury (IRI), than it should be susceptible to remote ischemic preconditioning (RIPC) as RIPC is a well validated technique to reduce IRI. To test this hypothesis healthy volunteers underwent a strenuous exercise test with or without preceding RIPC.

Enrollment

20 patients

Sex

All

Ages

18 to 45 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

age: 18-45 year
willing to sign informed consent
healthy

Exclusion criteria

hypertension (systolic blood pressure >140 mmHg or diastolic blood pressure > 90 mmHg)
any cardiovascular abnormality in past medical history, physical examination or ECG, including QTc interval
drug abuse
alcohol abuse (> 3 units/day)
smoking during the last 2 years
BMI >30 kg/m2
inability to perform bicycle test
the presence of an absolute or relative contra-indication for exercise (table 2 in protocol)
the presence of diabetes (fasting glucose > 6.9 mmol/L, non-fasting glucose >11.0 mmol/L; if non-fasting glucose is > 6.9 mmol/L, blood glucose measurement will be repeated in fasting condition and should then not exceed 6.9 mmol/L)
total cholesterol in blood 6.6 mmol/L or higher