Exercise to Slow Cardiovascular Ageing Progression

Singapore Health Services (SingHealth)

Status: Enrolling

Conditions: Cardiac Ageing; Cardiovascular; Exercise

Study type: Observational

Funder types: Other

Identifiers

NCT05775484

2022/2667

Details and patient eligibility

About

In ageing, deleterious alterations in cardiovascular (CV) structure and function increase risks of ageing-related cardiovascular disease (CVD). Investigators found that these CV alterations were associated with circulating serum metabolites, suggesting a metabolic basis to CV ageing. Investigators hypothesize that modification of these metabolites by intervention, such as exercise, may retard CV alterations and reduce CVD in ageing.

Full description

Participants from each stratum will be randomized to receive either an exercise program intervention or no exercise. At the start and end of study, participants will undergo cardiovascular imaging and metabolic profiling. Investigators will determine if exercise can reverse high-risk metabolic profiles and improve cardiovascular structure and function.

Without clear mechanisms to explain cardiovascular ageing nor interventions known to retard cardiovascular ageing, our approach will provide much needed translational evidence to incorporate targeted interventions aimed at reducing cardiovascular disease risk in older populations.

Enrollment: 450 estimated patients

Sex: All

Ages: 21 to 100 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age >=21 years old
• Outdoor ambulant

Exclusion criteria

• Wheelchair or bed-bound
• Dementia
• Residing in sheltered or nursing home
• Cancer
• Participation in ongoing clinical trials that involve interventional drugs or devices
• Aneurysms
• Acute infections (in the last six months)
• Uncontrolled thyrotoxicosis
• Neuromuscular, musculoskeletal or rheumatoid disorders that are exacerbated by exercise
• Uncontrolled asthma or chronic lung disease
• Restrictive lung disease

Trial design

450 participants in 4 patient groups

A

Description:

1. Cardiovascular measurements Non-invasive brachial blood pressure machine Echocardiography 2. Bio-specimen collection 3. Six-minute walk test 4. Musculoskeletal Analysis 5. Cardiopulmonary exercise test

B

Description:

1. Cardiovascular measurements Non-invasive brachial blood pressure machine Echocardiography 2. Bio-specimen collection 3. Six-minute walk test 4. Musculoskeletal Analysis

C

Description:

1. Cardiovascular measurements Non-invasive brachial blood pressure machine Echocardiography 2. Bio-specimen collection 3. Six-minute walk test 4. Musculoskeletal Analysis

D

Description:

1. Cardiovascular measurements Non-invasive brachial blood pressure machine Echocardiography 2. Bio-specimen collection 3. Six-minute walk test (may require separate day visit to complete) 4. Musculoskeletal Analysis 5. Questionnaires