Exercise Tolerance in Patients With CABG and Sternotomy vs. Patients With Minimally Invasive Coronary Surgery (ENDO-ACAB)

Hasselt University

Status: Completed

Conditions: Coronary Artery Bypass Surgery

Treatments: Other: Cardiopulmonary exercise test

Study type: Observational

Funder types: Other

Identifiers

NCT02433951

ENDO-ACAB study

Details and patient eligibility

About

In this study, up to 20 healthy individuals, 20 endo-ACAB patients, and 20 CABG patients undergo a maximal cardiopulmonary exercise test after hospital discharge (for patients only). Exercise tolerance is compared between groups.

Full description

In this prospective observational study, up to 20 healthy individuals (no history or presence of any chronic disease, sedentary), 20 endo-ACAB patients, and 20 CABG patients (matched for age, gender and BMI) undergo a maximal cardiopulmonary exercise test after hospital discharge (for patients only).During this exercise test, following parameters are assessed at peak effort and at the second ventilatory threshold (determined by VE/VCO2 slope method): oxygen uptake (VO2), oxygen saturation (SaO2), carbon dioxide output (VCO2), resoiratory gas exchange ratio (RER), expiratory volume (VE), ventilatory equivalent for VCO2 (VE/VCO2), ventilatory equivalent for VO2 (VE/VO2), end-tidal O2 pressure (PETO2), end-tidal CO2 pressure (PETCO2), heart rate (HR), oxygen pulse (VO2/HR), cycling power output (W), tidal volume (Vt), respiratory rate (RR), systolic blood pressure (SBP), diastolic blood pressure (DBP), rate pressure product (RPP). Peak exercise effort is validated by RERpeak.

Enrollment: 55 patients

Sex: All

Ages: 40 to 85 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• undergoing this type of surgery. For healthy subjects: must be sedentary.

Exclusion criteria

• any neurologic, nephrologic, respiratory disease. For healthy subjects: any chronic disease or condition.

Trial design

55 participants in 3 patient groups

healthy individuals

Description:

Age, gender and BMI matched healthy subjects without any chronic disease or physical disability, and being sedentary.

Treatment:

Other: Cardiopulmonary exercise test

CABG patients

Description:

Age, gender and BMI matched CABG patients, without neurologic, nephrologic, respiratory disease.

Treatment:

Other: Cardiopulmonary exercise test

endo-ACAB patients

Description:

Age, gender and BMI matched endo-ACAB patients without neurologic, nephrologic, respiratory disease.

Treatment:

Other: Cardiopulmonary exercise test