Exercise Training and Inflammatory Mediators in COPD

Faculty of Medicine, Sousse

Status: Completed

Conditions: COPD

Treatments: Other: Resistance Training RT; Other: Endurance Training ET

Study type: Interventional

Funder types: Other

Identifiers

NCT03853174

COPD and exercise

Details and patient eligibility

About

Chronic obstructive pulmonary disease (COPD) is widely spread all over the world. It is predicted to be the third leading cause of death by 2020[1]. COPD is a common, preventable treatable disease that is characterized by an airflow limitation which is not fully reversable[2].

Full description

Chronic obstructive pulmonary disease (COPD) is widely spread all over the world. It is predicted to be the third leading cause of death by 2020. COPD is a common, preventable treatable disease that is characterized by an airflow limitation which is not fully reversable.Not only the long-term exposition to noxious particles and gases contributes to the development of COPD, but also so many others factors such as genetics and cigarette smoking. It has been shown that cigarettes are harmful and contributed to different extra pulmonary disorders. Indeed, it induced a systemic inflammation that was considered as a key process in the pathogenesis of COPD and triggered the activation of inflammatory cells and an abnormal increase of circulating cytokines such as CRP, interleukin (IL6), IL8, tumor necrosis factor alpha (TNF alpha) and leptin.

Enrollment: 28 patients

Sex: Male

Ages: 40 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• COPD diagnosed by pulmonary function testing
• Clinically stable
• Abscence of other obstructive diseases
• Signed written consent

Exclusion criteria

• Neuromuscular diseases -Severe psychiatric, neurologic or musculoskeletal conditions and /or instable--- --
• cardiovascular diseases.
• Contre-indications to physical therapy
• Acute exacerbations a month before the intervention

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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28 participants in 2 patient groups

ET

Active Comparator group

Description:

Active Comparator: ET Endurance training were prformed. Intensity was gradually increased.

Treatment:

Other: Endurance Training ET

RT

Other group

Description:

Resistance training were prformed. Intensity was gradually increased.

Treatment:

Other: Resistance Training RT