Exercise Training and Testosterone Replacement in Heart Failure Patients

University of Sao Paulo General Hospital

Status and phase: Completed; Phase 4

Conditions: Heart Failure

Treatments: Drug: Testosterone replacement; Other: Exercise training

Study type: Interventional

Funder types: Other

Identifiers

NCT01852994

Testosterone

Details and patient eligibility

About

The purpose of this study is to determine if exercise training with or without testosterone replacement can improve cardiopathy in heart failure patients

Full description

In this study, we are evaluating:

• hospital length of stay and readmission
• muscle sympathetic nerve activity
• functional capacity
• body composition

Enrollment: 39 patients

Sex: Male

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• heart failure
• hypogonadism
• left ventricular fraction ejection < 45%

Exclusion criteria

• chronic renal failure
• normal testosterone
• pace maker

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: Single Blind

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39 participants in 3 patient groups

Exercise training

Other group

Description:

Aerobic and strength exercise training

Treatment:

Other: Exercise training

Testosterone replacement

Other group

Description:

Testosterone replacement will be done quarterly

Treatment:

Drug: Testosterone replacement

Testosterone replacement+Exercise

Other group

Description:

Both Testosterone replacement and Exercise will done

Treatment:

Other: Exercise training

Drug: Testosterone replacement