Exercise Training in Healthy Young Men

Maastricht University Medical Centre (MUMC)

Status: Completed

Conditions: Gaining Skeletal Muscle Mass and Strength

Treatments: Dietary Supplement: Exercise + Protein drink

Study type: Interventional

Funder types: Other

Identifiers

NCT02222415

MEC 11-03-45

Details and patient eligibility

About

Resistance type exercise training has been shown to be a potent stimulus to increase skeletal muscle mass and strength in healthy men. Furthermore, timed protein intake is also known to affect the muscle adaptive response following exercise. Whether timed protein intake could augment the increase in muscle fiber size and/or satellite cell content following long-term exercise intervention remains to be established.

We hypothesize that protein supplementation before sleep, on both training and non-training days, during a 12 week resistance training program further increases type II muscle fibre cross sectional area when compared to the placebo group.

Enrollment: 44 patients

Sex: Male

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Male
• Healthy
• Age between 18 and 30 years
• BMI between 18.5 and 30 kg/m2
• Recreationally active, performing sports on a non-competitive basis between 2 and 5 hours p/wk
• Participants willing and able to give written informed consent and to understand, to participate and to comply with the biomedical research project requirements

Exclusion criteria

• HbA1C level above 6.5%
• Fasted blood glucose level above 7 mmol/L
• Serum creatinine level beneath 60 or above 120 µmol/L
• Participants with a recent history or current state of COPD
• Participants with a recent history or current state of rheumatoid arthritis
• Participants with a recent history or current state of musculoskeletal/orthopedic disorders
• Participants with a recent history or current state of renal disorder
• Participants with a recent history or current state of cognitive impairment
• Participants with orthopedic metal implants in the spine and/or upper/lower extremities
• Participants with lactose intolerance and/or dairy protein allergy
• Participants who are enrolled in an interventional biomedical research project or have received an investigational new drug or product with the last 30 days prior to screening.
• Participants on medication, including anticoagulants

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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44 participants in 2 patient groups, including a placebo group

Training + placebo drink

Placebo Comparator group

Description:

Exercise + non-caloric placebo drink

Treatment:

Dietary Supplement: Exercise + Protein drink

Exercise + Protein drink

Experimental group

Description:

exercise + Drink containing Protein, Carbohydrates and Fat

Treatment:

Dietary Supplement: Exercise + Protein drink