Exercise Training in Obesity-prone Black and White Women

The University of Alabama at Birmingham

Status: Completed

Conditions: Obesity

Treatments: Behavioral: Diet; Behavioral: Aerobic exercise; Behavioral: Resistance exercise

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT00067873

R01DK049779 (U.S. NIH Grant/Contract)

BLKWHT (DK49779) (completed)

Details and patient eligibility

About

Overweight premenopausal Black and White women are randomized to either diet-only, diet+aerobic or diet+resistance exercise training. Diet/behavior intervention, with or without the aerobic or resistance exercise training, will be provided throughout the 18 months of study. Major outcomes will include measures of perceived and physiologic difficulty of exercise (cardiac, ventilatory, electromyographic responses to standardized exercise tasks); aerobic fitness; strength fitness; and spontaneous free-living energy expenditure (all derived from doubly labeled water). The results will provide insight into the effectiveness of, and the mechanisms by which, different types of exercise training can improve physical fitness, spontaneous engagement in physical activities of daily living and, in turn, weight-loss maintenance.

Full description

Overweight premenopausal Black and White women are randomized to either diet-only, diet+aerobic or diet+resistance exercise training. Diet/behavior intervention, with or without the aerobic or resistance exercise training, will be provided throughout the 18 months of study. Major outcomes will include measures of perceived and physiologic difficulty of exercise (cardiac, ventilatory, electromyographic responses to standardized exercise tasks); aerobic fitness; strength fitness; and spontaneous free-living energy expenditure (all derived from doubly labeled water). The results will provide insight into the effectiveness of, and the mechanisms by which, different types of exercise training can improve physical fitness, spontaneous engagement in physical activities of daily living and, in turn, weight-loss maintenance.

Time of initial weight loss was defined as the time needed to reach the goal of 25 kg/m2 BMI. The women will then be evaluated one year after this time and the amount of weight gain will be determined.

Enrollment: 231 patients

Sex: Female

Ages: 21 to 41 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

• Normoglycemic
• BMI between 27-30
• Non smoker
• Premenopausal
• Physically untrained
• Family history of obesity

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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231 participants in 3 patient groups

Diet only

Active Comparator group

Treatment:

Behavioral: Diet

Diet plus aerobic exercise

Experimental group

Treatment:

Behavioral: Aerobic exercise

Behavioral: Diet

Diet plus resistance exercise

Experimental group

Treatment:

Behavioral: Diet

Behavioral: Resistance exercise