Exercise Type That Faster Reduces Postprandial Glycemia. (GLYEXER)

University of Castilla-La Mancha

Status: Invitation-only

Conditions: Exercise-Induced Hyperinsulinism; Glucose, High Blood

Treatments: Behavioral: TYPE OF EXERCISE (OR REST)

Study type: Interventional

Funder types: Other

Identifiers

NCT04846751

PID2020-116159RB-I00

Details and patient eligibility

About

It is well established that a bout of 50 min of continuous moderate intensity exercise, improves insulin sensitivity up to 48 hours after the bout. However, it is less well known, what is the exercise type more efficient to buffer the elevations in blood glucose elicited by carbohydrate ingestion. The purpose of this study is to elucidate if intervalic exercise is superior to continous on improving postprandial glycemic control.

Full description

Carbohydrate oxidation, glucose and insulin blood concentrations, isotopically measured rate of appearance of endogenous and exogenous glucose will be measured in 4 ocassions.

Participants will undergo in a cross-over randomized fashion the following trials:

1. Exercise pedalling during 50 min at 60% of their VO2max followed by an oral glucose tolerance test (OGTT).
2. Exercise pedalling during 50 min in a hot environment (33ºC) at 60% of their VO2max followed by an oral glucose tolerance test (OGTT).
3. Exercise pedalling during 50 min using intervalic bouts averaging 60% of VO2max followed by an oral glucose tolerance test (OGTT).
4. No exercise, followed by an oral glucose tolerance test (OGTT).

Enrollment: 11 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Participant must be capable and willing to provide consent, understand, instructions and protocols.
• Minimal fitness level to be able to complete 50 min of continous exercise at a moderate intensity.

Exclusion criteria

• Smokers
• Pregnancy
• Any non-controlled medical condition which could influence results or could be worsened by exercise

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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11 participants in 2 patient groups, including a placebo group

AEROBIC EXERCISE

Active Comparator group

Description:

50 min of aerobic exercise by pedaling a cycleergometer at 60% of VO2max

Treatment:

Behavioral: TYPE OF EXERCISE (OR REST)

PLACEBO REST

Placebo Comparator group

Description:

No exercise, resting during 50 min.

Treatment:

Behavioral: TYPE OF EXERCISE (OR REST)