Exogenous Ketone Supplementation and Exercise Performance

Western University, Canada

Status: Unknown

Conditions: Ketosis; Ketonemia

Treatments: Dietary Supplement: Ketone; Dietary Supplement: Water Placebo; Behavioral: 20 km time trial; Behavioral: Wingate test; Dietary Supplement: Ketone/Caffeine

Study type: Interventional

Funder types: Other

Identifiers

NCT03895892

113474

Details and patient eligibility

About

20 healthy recreationally active men and woman aged 18-35 will participate in the study. There will be three treatments involved: Caffeinated ketone supplements, non-caffeinated ketone supplement and water-placebo. Participants will complete the protocol three times and the treatment order will be systematically rotated to avoid any order effect. The three main trials will be separated by at least 1 week. After providing the corresponding treatment, participants will be given 30 minutes and after, they will perform a standardized 10-minute warm-up, followed by the 20 km time trial and a 30-second all-out Wingate test.

Full description

Some researchers support that a state of ketosis, reached through the use of ketogenic diet, has the potential to improve athletic. To attain such state, individuals must restrict carbohydrate intake to a maximum of 50g/ day or 10% while keeping protein intake moderate. One of the biggest challenges to achieve and maintain ketosis is complying with the diet due to its restrictive nature. Consequently, manufacturers have developed supplements that can induce a state of ketosis acutely (~1 hour). Unfortunately, there is very little evidence supporting the use of these supplements to enhance athletic performance. Hyperketonemia (blood ketone concentration > 0.2 Mm) seems to elevate the rate of utilization of ketone bodies. These changes in substrate utilization may allow athletes to preserve, something that would be advantageous for exercise performance. Ketone salts have been shown to elevate the concentration of ketones in blood and as such they may allow the body benefit from the apparent sparing of carbohydrates. Manufacturers now provide ketones salts combined with other ingredients such as caffeine. However it is unknown whether or not the addition of these ingredients has any positive or negative effect on athletic performance. Caffeine alone has been shown to improve athletic performance in several studies. Therefore, the purpose of this study is to compare the effectiveness of a caffeine free ketone salt supplement vs a caffeinated ketone salt supplement and their effects on a 20km time trial and a 30 second all-out Wingate test.

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy male and female recreationally active individuals
• aged 15-35 years
• non regular caffeine users.

Exclusion criteria

• Smoker
• Taking part in other research
• Sedentary
• For women, if they are pregnant or become pregnant during the study
• Injury limiting exercise ability.
• Have symptoms or take medication for respiratory disease
• Have symptoms or take medication for cardiovascular disease
• Have symptoms or take mediation for neuromuscular disease
• Use heart rate or blood pressure medications
• Use any medications with side effects of dizziness, lack of motor control, or slowed reaction time

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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20 participants in 3 patient groups, including a placebo group

Water Placebo

Placebo Comparator group

Description:

Placebo flavored drink similar to treatments but with no energy will be ingested before completing a 20km Time trial and a 30 second all-out Wingate test

Treatment:

Behavioral: 20 km time trial

Behavioral: Wingate test

Dietary Supplement: Water Placebo

Experimental 1

Experimental group

Description:

Ketone salts supplement mixed in water will be ingested before completing a 20km Time trial and a 30 second all-out Wingate test

Treatment:

Behavioral: 20 km time trial

Dietary Supplement: Ketone

Behavioral: Wingate test

Experimental 2

Experimental group

Description:

Ketone salts/caffeine supplement mixed in water will be ingested before completing a 20km Time trial and a 30 second all-out Wingate test

Treatment:

Behavioral: 20 km time trial

Behavioral: Wingate test

Dietary Supplement: Ketone/Caffeine