Exogenous Ketones and Glucose Tolerance
Status and phase
Conditions
Treatments
Details and patient eligibility
About
The ketone body beta-hydroxybutyrate is produced during prolonged fasting or when endogenous carbohydrate stores are depleted and can be used as an alternative fuel source. Exogenous beta-hydroxybutyrate, in the form of a ketone monoester, is proposed to have glucose-lowering potential but this has not been adequately studied. The purpose of this study is to determine whether supplementing with an acute dose of ketone monoester can improve the glycemic response to an oral glucose tolerance test in individuals with impaired fasting glucose.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
- Not taking any medications affecting glucose metabolism.
- Elevated fasting glucose level (5.6-6.9 mmol/L) OR body mass index >28 kg/m2 OR elevated waist circumference (>102 cm for males, >88 cm for females)
Exclusion criteria
- Diagnosed with diabetes.
- Diagnosed with heart disease.
- Competitive endurance athlete (self-identified as engaged in specific endurance training in triathlon, cycling, or distance running and competing in races or competition)
- Recent (last 3 months) or current consumption of a low-carbohydrate ketogenic diet
- Current consumption of ketone supplements
- Pregnant or planning to become pregnant during the study (if female)
Trial design
Primary purpose
Allocation
Interventional model
Masking
15 participants in 2 patient groups, including a placebo group
Trial contacts and locations
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Data sourced from clinicaltrials.gov
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