Exosomes Implication in PD1-PD-L1 Activation in OSAS (ExoSAS)

University Hospital, Angers

Status: Completed

Conditions: Sleep Apnea Syndromes, Obstructive; Cancer

Treatments: Diagnostic Test: PD1/PD-L1 exosomal expression

Study type: Observational

Funder types: Other

Identifiers

NCT03811600

2019-A00029-48

Details and patient eligibility

About

An increased occurrence of cancer associated mortality has been described in patients with Obstructive Sleep Apnea Syndrome (OSAS). This association might be partially explained by an impaired cellular immune response that has been described in OSAS. Is has been suggested that OSAS impact immune cells by upregulation of the PD-1/PD-L1 pathway. Exosomes are small membrane vesicles released by numerous cells in the bloodstream. Exosomes have been shown to be implicated in cancer cells proliferation via a PD-1/PD-L1 pathway activation.

This study will evaluate exosomal PD-1/PD-L1 expression in patients with OSAS as compared to controls and will further investigate their impact on immune cells function and proliferation capacities.

Enrollment: 90 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients requiring a sleep recording for suspected OSAS

Exclusion criteria

• Préviously treated OSAS
• Cancer past history
• Pregnant women
• Cognitif impairment

Trial design

90 participants in 2 patient groups

OSAS patients

Description:

45 patients investigated for suspected OSAS with an apnea hypopnea index ≥15 per hour

Treatment:

Diagnostic Test: PD1/PD-L1 exosomal expression

Non OSAS patients

Description:

45 patients investigated for suspected OSAS with an apnea hypopnea index <15 per hour

Treatment:

Diagnostic Test: PD1/PD-L1 exosomal expression