Expectant Versus Immediate Medical Management for the Evacuation of the no Evolutionary Pregnancies Before 13 GW

Assistance Publique - Hôpitaux de Paris

Status and phase

Completed

Phase 4

Conditions

Pregnancy Complications

Treatments

Drug: MIFEPRISTONE 200 mg and misoprostol 400 µg

Study type

Interventional

Funder types

Other

Identifiers

NCT00190294

P011017

Details and patient eligibility

About

Compared the interest of one week expectancy vs immediate medical treatment in the taking care of the evacuation of the no evolutionary pregnancies before 13 GW.

Full description

Randomized control trial comparing one week expectancy vs immediate medical treatment (mifepristone 200mg and misoprostol 400ug) in the taking care of the evacuation of the no evolutionary pregnancies before 13 GW.

Enrollment

200 patients

Sex

Female

Ages

18 to 48 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Agreed women aged over 18 yrs old

Non evolutive pregnancy before 13GW :

Non evolutive pregnancy with no fetal cardiac activity
Non evolutive pregnancy with embryonic structures
Trophoblastic material in uterine cavity P bhCG < 10UI/L

Exclusion criteria

Age < 18 years
pregnancy evolutionary
not evolutionary pregnancy after 13 weeks of amenorrhoea characterized by the presence of an scan image intra-uterine ANECHOGENE furthermore of 50mm of diameter
amenorrhoea of more than 13 weeks
pregnancy twin
pregnancy molar
pregnancy extra-uterine
Extra-uterine pregnancy
one or many contraindications in the mifepristone:
Allergy known about the MIFEPRISTONE
Incapacity suprarenal
corticosteroid therapy in the long price
confusions of the haemostasis (thrombopenia < in 100000 / mm3)
anaemia (rate Hg < in 9 g / dl)
contraindication in the misoprostol
allergy known about PROSTAGLANDINES
BEANCE cervical