Experimental Overfeeding in Humans (ExpO)

University of Copenhagen

Status: Completed

Conditions: Overfed; Obesity

Treatments: Other: Isocaloric diet; Other: Overfeeding diet

Study type: Interventional

Funder types: Other

Identifiers

NCT04065243

ExpO

Details and patient eligibility

About

The objective of this study is to determine the homeostatic mechanisms that counteract weight gain in response to experimental overfeeding.

Full description

The homeostatic regulation of body weight implies that biological processes have evolved to protect energy stores from changes to the food environment. Accordingly, many individuals remain remarkably weight stable over years without carefully considering how much they eat or how much energy they expend, which has given rise to the theory that body weight is regulated around an individual biological 'set point'. Notably, overfeeding humans in experimentally controlled conditions, support this phenomenon, but the underlying mechanisms are unknown.

To systematically map out the components of the overfed state, the investigators will execute a 2-week randomized controlled overfeeding trial in lean and overweight individuals. The trial is preceded by a 1-week lead-in period and followed by a 2-wk controlled ad libitum study period. The comparison between lean and overweight subjects, men and women, enables the determination of whether a differential response in overfeeding-induced signals is present in relation to BMI and sex.

Enrollment: 24 patients

Sex: All

Ages: 20 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Male or female otherwise healthy subjects
• 20-40 years of age
• BMI (Body mass index) between 22-30 kg/m2

Exclusion criteria

• Present or previous cardiovascular disease, diabetes or thyroid-disease
• smoking
• more than 3 hours of planned physical activity per week

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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24 participants in 2 patient groups

Control group

Active Comparator group

Description:

Subjects in this group will have a daily energy intake equivalent of 100 % of their calculated normal daily energy intake.

Treatment:

Other: Isocaloric diet

Overfed group

Experimental group

Description:

Subjects in this group will have a daily energy intake equivalent of 150 % of their calculated normal daily energy intake.

Treatment:

Other: Overfeeding diet