Experimental Therapeutics in Essential Tremor Using Transcranial Direct Current Stimulation (ELECTRE)

Institut National de la Santé Et de la Recherche Médicale, France

Status

Completed

Conditions

Essential Tremor

Treatments

Device: transcranial direct current stimulation

Study type

Interventional

Funder types

Other

Identifiers

NCT01579435

C11-37

2011-A01453-38 (Registry Identifier)

Details and patient eligibility

About

The purpose of this study is to determine whether transcranial direct current stimulation (tDCS) delivered over the motor cortex or the cerebellum can improve essential tremor and to identify the cerebral mechanisms involved in these potential effects.

Enrollment

12 patients

Sex

All

Ages

18 to 50 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age ≥ 18 years and < 50 years
Important essential tremor (bilateral postural and/or action tremor since more than one year)
Normal physical and neurological examination, except for essential tremor
Insufficient efficiency of usual essential tremor's treatment
No treatment altering the cortical excitability
Agreement to use a medically acceptable method of contraception throughout the study for female of childbearing potential

Exclusion criteria

Cervical tremor
Current neurological or psychiatric illness other than essential tremor
Individual who is on medication which is known to lower seizure threshold
Previous history of seizure(s), malaise or current active epilepsy
Contraindication for MRI or TMS study
Pregnancy, breast feeding women and women who are of childbearing age and not practicing adequate birth control
Individual who have MMS ≤ 24/30 or patients legally protected or inability to provide an informed consent
Simultaneous participation in another clinical trial
Patients who are not enrolled at social security