Exploration of Cerebral Pathophysiology During and After CABG Using CPB
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Purpose:
The purpose of this study is to examine cerebral oxidative and inflammatory stress and cerebral hemodynamics during and after coronary artery bypass grafting and correlate with postoperative cognitive function.
Full description
Postoperative cognitive decline is a well-known and well-described complication following coronary artery bypass grafting. Severity ranges from postoperative delirium to stroke, but the majority of patients with postoperative cognitive decline following coronary artery bypass grafting have decline in recent and remote memory in particular.
The reason for the cognitive decline is still not fully understood though many reasons have been proposed.
Inflammation and oxidative stress may contribute to the postoperative cognitive dysfunction which may also be in combination with a reduced cerebral autoregulation.
Enrollment
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Inclusion criteria
- Patients with ischemic heart disease admitted for coronary artery bypass grafting with the use of cardiopulmonary bypass
Exclusion criteria
- Cerebrovascular disease
Trial design
24 participants in 1 patient group
Trial contacts and locations
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Data sourced from clinicaltrials.gov
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