Exploration of eJaculatory Anatomy Concept Study (EJAC Study)

Clinique Pasteur

Status

Completed

Conditions

Ejaculatory Dysfunction

Treatments

Other: Urethroscopy

Other: Transrectal ultrasound

Study type

Interventional

Funder types

Other

Identifiers

NCT05650853

2022-A01594-39

Details and patient eligibility

About

Ejaculatory dysfunctions (ED) are an important cause of postoperative dissatisfaction, which lead to a decrease in the intensity of orgasms in 50% of patients. ED is a cause for concern for almost a third of patients who need surgery. Surgical techniques have been developed to limit the occurrence of postoperative ED, but their results remain heterogeneous.

There are very few studies on the biomechanical anatomy of ejaculation. Ejaculation is a complex phenomenon involving different structures and in particular the Veru Montanum. This is the key element in the emission of ejaculate within the prostatic urethra. In addition, there is a structure located in the resection zone of the prostate adenoma. It has therefore been suggested that its resection was a primary source of ED.

A single observational study carried out in by Gil Vernet et al in 1994 evaluated on a single healthy 18-year-old volunteer the ejaculatory mechanism of expulsion using an endorectal probe recording the movements of the prostate, the bladder neck and of the proximal urethra during ejaculation.

A contemporary study of the biomechanics of the ejaculatory expulsion phase could confirm and improve understanding of the involvement of anatomical structures. The results of our study aim to adapt surgical techniques aimed at limiting the risk of postoperative ED.

Enrollment

3 patients

Sex

Male

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Affiliated subject or beneficiary of a social security scheme
Subject agreeing to participate and having signed the free, informed consent.

Exclusion criteria

Subject with ejaculatory dysfunction
Subject with urinary dysfunction
History of urinary or penile surgery
Subject with untreated urinary tract infection
History of chronic prostatitis
Pathology making it impossible to introduce the endorectal probe or the ureteroscope
History of colorectal inflammatory disease
Recent intake (within 30 days) of drugs known to interfere with ejaculation
History of intolerance or allergy to any of the drugs used in the study
Subject participating in another clinical study
Adults under guardianship, curatorship or other legal protection; deprived of liberty by judicial or administrative decision; Hospitalized without consent.