Exploration of Mechanisms for Weaning Failure

Guangzhou Medical University

Status: Enrolling

Conditions: Weaning Failure; Central Respiratory Depression; Diaphragm Injury; Phrenic Nerve Disorder

Treatments: Diagnostic Test: Monitoring of respiratory mechanics parameters

Study type: Observational

Funder types: Other

Identifiers

NCT06424314

202220252311

Details and patient eligibility

About

This study is a prospective physiologic study. The primary study population will be adult invasive tracheal intubated patients with COPD, and investigators will collect relevant demographic data, vital signs, and baseline physiologic parameters of the patients prior to the spontaneous breathing test（SBT).

The participants will be divided into a successful withdrawal group and a failed withdrawal group according to the SBT outcome, and the changes in the above parameters during SBT will be compared between the two groups .

Full description

This observational study mainly include participants who had invasive mechanical ventilation for ≥48 h and are assessed to be ready for the SBT trial.The SBT approach is based on the low-level pressure support mode.

Prior to the SBT trial, baseline demographic and physiologic data of the participants will be collected, and the participants will be divided into two groups based on the results of the SBT trial: successful and unsuccessful, and the physiologic changes during the SBT trial will be compared between the two groups, respectively.

Enrollment: 30 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Invasive mechanical ventilation for at least 48 hours

Exclusion criteria

• neuromuscular disease；Postoperative patients or patients with traumatic brain injury

Trial design

30 participants in 2 patient groups

weaning success

Description:

Patient passed SBT test with no need to receive invasive mechanical ventilation 48 hours after extubation

Treatment:

Diagnostic Test: Monitoring of respiratory mechanics parameters

weaning failure

Description:

Patient failed SBT test or need to receive invasive mechanical ventilation 48 hours after extubation

Treatment:

Diagnostic Test: Monitoring of respiratory mechanics parameters