Exploration of the Appropriate Combination of Positive End Expiratory Pressure and Tidal Volume Using the Intratidal Compliance Volume Profile in Children

Seoul National University

Status: Completed

Conditions: Respiratory Compliance

Treatments: Other: Changes in positive end-expiratory pressure and tidal volume

Study type: Interventional

Funder types: Other

Identifiers

NCT04633720

H2009-175-1162

Details and patient eligibility

About

In children under 6 years of age undergoing regular surgery during general anesthesia, the intratidal compliance profile is evaluated when different tidal volumes are applied at different positive end expiratory pressures.

Then determine the most appropriate combination of positive end-tidal pressure and tidal volume.

Enrollment: 43 patients

Sex: All

Ages: 1 month to 6 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Children undergoing surgery > 1 hour under general anesthesia
• Children ≤ 6 years
• American society of anesthesiology physical status I, II

Exclusion criteria

• Previous lung surgery
• Bronchopulmonary dysplasia, respiratory distress syndrome
• Other interstitial lung disease
• Laparoscopic surgery
• Thoracic surgery, abdominal surgery

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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43 participants in 1 patient group

Evaluation of intratidal compliance

Experimental group

Description:

When the patient is in the supine position 10 minutes after induction of anesthesia, the following 4 mechanical ventilator settings are applied to the patients in order. 1. Positive end-expiratory pressure 8 cmH2O, tidal volume 8 ml/kg 2. Positive end-expiratory pressure 10 cmH2O, tidal volume 5 ml/kg 3. Positive end-expiratory pressure 10 cmH2O, tidal volume 8 ml/kg 4. Positive end-expiratory pressure 12 cmH2O, tidal volume 5 ml/kg

Treatment:

Other: Changes in positive end-expiratory pressure and tidal volume