Exploration of the Relationship Between Inflammation and Integrity of the Blood-Brain Barrier in Suicidal Behaviour (IBIS)

University Hospital Center (CHU)

Status

Unknown

Conditions

Depression

Treatments

Biological: Biological analysis

Study type

Interventional

Funder types

Other

Identifiers

NCT04137458

2019-A01277-50 (Other Identifier)

RECHMPL19_0227

Details and patient eligibility

About

Recent studies have revealed an association between history of suicide attempt and inflammatory markers in both the cerebrospinal fluid and the plasma. Post mortem studies have shown an increase in microglial activation in the brain tissue of suicide victims. However the relationship between peripheral and central inflammation in suicide is probably mediated by complex biological processes that are yet elucidated. An increase of blood S100B levels (biomarker of neurovascular damage; PMID 14530574) has been reported in adolescents with suicidal ideation vs. controls and independently of psychiatric disorder. The investigators hypothesize that peripheral inflammation may alter BBB which normally acts as a filter to ensure proper neuronal functioning in suicidal vs. non suicidal patients.

Full description

105 participants will be recruited :

35 depressed patients having attempted suicide (maximum 3 attempts in life)
35 depressed patients without history of suicide attempt (affective controls)
35 healhy controls with no lifetime psychiatric history.

Only one visit is planned. A clinical assessment (2 hours) will be performed to characterise pschopathology and suicidal characteristics. Blood and salivary samples will be obtained in order to measure inflammatory markers.

Enrollment

105 estimated patients

Sex

All

Ages

18 to 55 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

18-55 years old
Able to understand nature, aims, and methodology of the study

Depending on the population :

Current depressive episode (according to DSM-5 criteria) with a recent suicide attempt (within the 8 days before inclusion) and no more than 3 attempts in life
Current depressive episode (according to DSM-5 criteria) without suicide attempt
No psychiatric history (according to DSM-5 criteria)

Exclusion criteria

Inflammatory diseases or intercurrent infections, or chronic diseases such as hepatitis C or B, HIV, Alzheimer's, cancer or autoimmune disease
Current antibiotic or anti-inflammatory treatments
Refusal to participate
Lifetime Schizoaffective disorder or schizophrenia
On protective measures (guardianship or trusteeship)
Deprived of liberty subject (administrative decision)
In exclusion period for another protocol
Not affiliated to a social security agency
Unable to understand and/or answer a questionnaire
Pregnant or lactating women