Exploration of the Synovial Fluid Inflammation Mediators Under Diacerhein in Knee Osteoarthritis

Laboratoires NEGMA

Status and phase: Completed; Phase 4

Conditions: Osteoarthritis

Treatments: Drug: Diacerhein

Study type: Interventional

Funder types: Industry

Identifiers

NCT00440661

HEC/ART06572N

109196

Details and patient eligibility

About

Some inflammation mediators, notably IL-1, are implied in the joint degeneration phenomena of osteoarthritis. The aim of this study is to confirm in vivo the favourable effect of diacerhein on IL-1 and also to appreciate its effect on other synovial inflammation mediators.

Enrollment: 96 estimated patients

Sex: All

Ages: 45 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Painful osteoarthritis
• Hydarthrosis (synovial effusion)

Exclusion criteria

• large effusion
• severe pathologies
• anti-osteoarthritic treatments

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind