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Exploratory Study of Natural Killer Cells in Human Skin

P

Public Assistance-Hospitals of Marseille (AP-HM)

Status

Completed

Conditions

Atopic Dermatitis
Graft Versus Host Disease
Psoriasis
Melanoma
Contact Dermatitis
Lichen Planus

Treatments

Other: Biopsy and sample of blood

Study type

Interventional

Funder types

Other

Identifiers

NCT00824889
2008-03
2008-A00064-51

Details and patient eligibility

About

Natural Killer (NK) cells play a unique role during innate immune responses as they are able to recognize and eliminate, without specific sensitization, tumors, microbe-infected cells as well as allogeneic cells.In a first time, we will characterize the tissue distribution, the phenotype and the effector functions of NK cells present in the human healthy skin.

Full description

Then, we will define whether these parameters are qualitatively/ quantitatively modified in the following skin pathologies: a) atopic dermatitis; b) contact dermatitis; c) psoriasis ; d) lichen planus ; e) GVH (graft versus host disease) ; (f) melanoma.

Read more

Enrollment

28 patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Age ≥ 18 years.
  • Consent obtained after healthy donor or patient information.
  • Patients suffering from one of the following diseases: a) atopic dermatitis ; b) contact dermatitis; c) psoriasis ; d) lichen planus ; e) GVH ; f) melanoma.

Exclusion criteria

  • Age below 18,
  • pregnant or breastfeeding women,
  • persons under guardianship, persons without social security, prisoners, persons hospitalized without consent on the basis of French laws L. 3212-1 et L. 3213-1. Patients affected by HIV infection, AIDS, Hepatitis A, B or C infection.
  • Neutropenia <1000/mm3.
  • Thrombopenia <50 000/mm3.

Trial design

28 participants in 7 patient groups

1
Other group
Description:
Healthy volunteer
Treatment:
Other: Biopsy and sample of blood
Other: Biopsy and sample of blood
Other: Biopsy and sample of blood
Other: Biopsy and sample of blood
Other: Biopsy and sample of blood
Other: Biopsy and sample of blood
Other: Biopsy and sample of blood
2
Other group
Description:
atopic dermatitis patient
Treatment:
Other: Biopsy and sample of blood
Other: Biopsy and sample of blood
Other: Biopsy and sample of blood
Other: Biopsy and sample of blood
Other: Biopsy and sample of blood
Other: Biopsy and sample of blood
Other: Biopsy and sample of blood
3
Other group
Description:
contact dermatitis patient
Treatment:
Other: Biopsy and sample of blood
Other: Biopsy and sample of blood
Other: Biopsy and sample of blood
Other: Biopsy and sample of blood
Other: Biopsy and sample of blood
Other: Biopsy and sample of blood
Other: Biopsy and sample of blood
4
Other group
Description:
psoriasis patient
Treatment:
Other: Biopsy and sample of blood
Other: Biopsy and sample of blood
Other: Biopsy and sample of blood
Other: Biopsy and sample of blood
Other: Biopsy and sample of blood
Other: Biopsy and sample of blood
Other: Biopsy and sample of blood
5
Other group
Description:
lichen planus patient
Treatment:
Other: Biopsy and sample of blood
Other: Biopsy and sample of blood
Other: Biopsy and sample of blood
Other: Biopsy and sample of blood
Other: Biopsy and sample of blood
Other: Biopsy and sample of blood
Other: Biopsy and sample of blood
6
Other group
Description:
GVH patient
Treatment:
Other: Biopsy and sample of blood
Other: Biopsy and sample of blood
Other: Biopsy and sample of blood
Other: Biopsy and sample of blood
Other: Biopsy and sample of blood
Other: Biopsy and sample of blood
Other: Biopsy and sample of blood
7
Other group
Description:
melanoma patient
Treatment:
Other: Biopsy and sample of blood
Other: Biopsy and sample of blood
Other: Biopsy and sample of blood
Other: Biopsy and sample of blood
Other: Biopsy and sample of blood
Other: Biopsy and sample of blood
Other: Biopsy and sample of blood

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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