Exploratory Study of Relationships Between Malodor and Urine Metabolomics

Mebo Research

Status: Completed

Conditions: Nutritional and Metabolic Diseases

Study type: Observational

Funder types: Other

Identifiers

NCT02683876

201505010014MEBO

Details and patient eligibility

About

The purpose of this study is to identify metabolic signatures associated with malodor conditions. The investigators will perform state-of-the art metabolomics tests and bioinformatic data mining to explore if conditions leading to malodor can be screened by metabolomic profiling of urine samples.

Full description

In this study, metabolite profiling analysis will be carried out on urine samples of individuals with malodor conditions related to metabolism inefficiencies. Metabolic profiles will be identified using the metabolomics equipment located in the NMR, HPLC and MS facilities of the Metabolomics Innovation Centre (TMIC). Multivariate statistical analyses will be used, as well as other approaches to mine complex data from heterogeneous sources.

Enrollment: 39 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18 years or older
• unpredictable and uncontrollable episodes of malodor
• willing and able to ship a urine sample (in the kit provided) by an overnight courier to Edmonton, Alberta, Canada
• good general health

Exclusion criteria

• serious medical conditions that require treatment
• conditions that, in the opinion of the investigator, would prevent participation
• under the age of 18
• elect not to participate in the study

Trial design

39 participants in 2 patient groups

Subjects with malodor

Description:

individuals with self-reported odor issues suspected to be associated with microbial imbalance on or inside the body and inefficient metabolism as evidenced from other laboratory tests

Healthy control

Description:

individuals not complaining of uncontrollable or unpredictable malodor episodes